Probabilities

Probability (%)*
 
•Probability of diagnosing LTBI

25

Assumption

•Probability of completing LTBI treatment among those who start it

70.8

[69]

•Probability of reactivation of longstanding LTBI to TB disease (nonsmokers)

0.05/year

[70,71,72]

•Probability of rapid progression following TB infection (nonsmokers)**

4.5/year for 2 years

Dynamic model^{#}

•Probability of diagnosing active disease

90

Assumption

•Probability of spontaneous resolution of untreated TB disease

25

[16]

•Probability of relapse following spontaneously resolved TB

2.5

[16, 73]

•Probability of dying from untreated TB

19/year

[74, 75]

•Probability of relapse after treated TB disease in first year

1.5

[76]

•Protective immunity from previous TB disease

55

Dynamic model^{#}

QALYs for LTBI and active TB

Value (range)
 
•Utility score for individual with active disease (treated)

0.85 (0.70–0.90)

[40]

•Utility score for individual with active disease (untreated)

0.68 (0.65–0.72)

[39]

•Utility score for individual with latent infection, during treatment

0.97 (0.95–1.00)

[40]

•Utility score for individual with latent infection (untreated)

1

Assumption^{†}
