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Fig. 3 | BMC Medicine

Fig. 3

From: Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

Fig. 3

CRAMP increases FoxO3a phosphorylation and nuclear export in apoptotic cardiomyocytes. a, b Western blot analysis for FoxO3a phosphorylation after stimulation with the rCRAMP peptide (a, n = 6) or transfection with the siRNA targeting rCRAMP (b, n = 6) in neonatal rat cardiomyocytes (NRCMs) treated with oxygen glucose deprivation/reperfusion (OGDR) or not. All membranes were probed, stripped, and then reprobed for determining the phosphorylation level of FoxO3a. c, d Western blot analysis for FoxO3a subcellular expression in the cytoplasm or nucleus after stimulation with the rCRAMP peptide (c, n = 6) or transfection with the siRNA targeting rCRAMP (d, n = 6) in NRCMs treated with OGDR or not. Data were expressed as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001

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