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Fig. 7 | BMC Medicine

Fig. 7

From: Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

Fig. 7

c-Jun negatively regulates CRAMP in the control of cardiomyocyte apoptosis. a The cardiomyocyte apoptosis was measured by TUNEL staining after transfection with siRNAs targeting Rela, c-Jun, and rCRAMP in neonatal rat cardiomyocytes (NRCMs) treated with oxygen glucose deprivation/reperfusion (OGDR) (n = 4). Immunofluorescent staining for α-actinin was used to label cardiomyocytes. b The cardiomyocyte apoptosis was measured by Western blot (n = 3) after transfection with siRNAs targeting c-Jun and rCRAMP in NRCMs treated with OGDR. c qRT-PCR for rCRAMP mRNA level in NRCMs transfected with c-Jun siRNA (n = 4). Scale bar = 100 μm (a). Data were expressed as mean ± SD. *P < 0.05 vs. OGDR+si-NC group; **P < 0.01 vs. OGDR+si-NC group; ***P < 0.001 vs. OGDR+si-NC group; ##P < 0.01 vs. OGDR+si-CRAMP group; §§P < 0.01 vs. OGDR+si-Jun group

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