Fig. 9
From: Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury
The proposed mechanism for the protective effect of CRAMP against cardiomyocyte apoptosis and myocardial ischemia/reperfusion (I/R) injury. Induced c-Jun and reduced CRAMP were identified in the heart upon I/R injury. CRAMP protects against cardiomyocyte apoptosis and myocardial I/R injury via the activation of Akt and ERK1/2 pathways and the phosphorylation and nuclear export of FoxO3a