Fig. 5
From: Repeated clinical malaria episodes are associated with modification of the immune system in children
Cell-specific gene expression profiles inferred from cellular deconvolution of transcriptome reveal transcriptionally altered CD8+ T cells, neutrophils and B cells in high-episode children. a RNA expression of canonical cellular lineage-associated markers strongly correlated with inferred cell-specific profiles, suggesting that cell-specific gene expression patterns can be successfully deconvolved from cell sub-type proportions and RNA levels. b Using scrambled data to infer false discovery rate, cell-specific gene contributions were selected. Focusing on cell populations with at least ten genes altered, high-episode children show transcriptionally altered CD8+ T cells, neutrophils and B cells. Heatmap illustrates the expression level of cell-specific genes in high-episode children relative to low-episode children