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Table 1 Mendelian randomization estimates of associations of genetically predicted linoleic acid with ischemic heart disease (IHD) and diabetes using different SNP selections

From: Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study

Exposure

Selection of SNPs

Method

#SNPs

IHD

Diabetes

OR

95% CI

p

OR

95% CI

p

Linoleic acid (% in total fatty acids)

Genome-wide significant and functionally relevant SNPs

PCA

47

1.01

0.95 to 1.08

0.71

0.97

0.96 to 0.99

< 0.001

Most significant SNPs

IVW*

3

0.99

0.96 to 1.01

0.18

0.97

0.95 to 0.99

0.001

All genome-wide significant SNPs

PCA

167

1.00

0.96 to 1.05

0.92

0.98

0.96 to 0.99

0.001

DPA (% in total fatty acids)

Most significant SNPs in GWAS of n-3 PUFA (rs780094 and rs3734398)

IVW†

2

1.10

0.77 to 1.59

0.60

0.45

0.10 to 2.02

0.30

  1. CI confidence interval, DPA docosapentaenoic acid, IVW inverse variance weighting, OR odds ratio, PCA principal components analysis, PUFA polyunsaturated fatty acid
  2. *IVW with fixed effects was used for diabetes, and IVW with random effects (heterogeneity test p value < 0.05) was used for IHD
  3. †IVW with fixed effects was used for IHD, and IVW with random effects (heterogeneity test p value < 0.05) was used for diabetes