Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study

Zhao, Jie V.; Schooling, C. Mary

doi:10.1186/s12916-019-1293-x

Table 2 Mendelian randomization estimates of associations of genetically predicted linoleic acid with lipids, blood pressure, and reticulocyte count using different SNP selections

From: Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study

Outcome	Selection of SNPs	Method	#SNPs	Beta	95% CI	p
LDL cholesterol	Genome-wide significant and functionally relevant SNPs	PCA	47	− 0.032	− 0.037 to − 0.027	< 0.001
	Most significant SNPs	IVW	3	− 0.034	− 0.039 to − 0.029	< 0.001
	All genome-wide significant SNPs	PCA	167	− 0.033	− 0.038 to − 0.028	< 0.001
HDL cholesterol	Genome-wide significant and functionally relevant SNPs	PCA	47	− 0.026	− 0.031 to − 0.021	< 0.001
	Most significant SNPs	IVW^†	3	− 0.028	− 0.039 to − 0.016	< 0.001
	All genome-wide significant SNPs*	PCA	141	− 0.027	−0.032 to − 0.022	< 0.001
Total cholesterol	Genome-wide significant and functionally relevant SNPs	PCA	47	− 0.030	−0.035 to − 0.026	< 0.001
	Most significant SNPs	IVW^†	3	− 0.032	− 0.040 to − 0.023	< 0.001
	All genome-wide significant SNPs	PCA	167	− 0.028	− 0.047 to − 0.010	0.003
DBP	Genome-wide significant and functionally relevant SNPs	PCA	47	0.006	0.003 to 0.009	< 0.001
	Most significant SNPs	IVW^†	3	0.008	− 0.005 to 0.020	0.23
	All genome-wide significant SNPs*	PCA	141	0.006	0.003 to 0.009	< 0.001
SBP	Genome-wide significant and functionally relevant SNPs	PCA	47	− 0.001	− 0.004 to 0.002	0.62
	Most significant SNPs	IVW^†	3	0.001	− 0.008 to 0.009	0.90
	All genome-wide significant SNPs	PCA	167	0.010	− 0.007 to 0.027	0.24
Reticulocyte count	Genome-wide significant and functionally relevant SNPs	PCA	47	0.001	− 0.022 to 0.024	0.93
	Most significant SNPs	IVW^†	3	0.013	− 0.001 to 0.027	0.08
	All genome-wide significant SNPs*	PCA	141	0.002	− 0.020 to 0.023	0.88

DBP diastolic blood pressure, HDL high-density lipoprotein, IVW inverse variance weighting, LDL low-density lipoprotein, PCA principal components analysis, SBP systolic blood pressure
*Twenty-six highly correlated SNPs were excluded due to potential pleiotropy with HDL cholesterol, DBP, and reticulocyte count
^†IVW with random effects (heterogeneity test p value < 0.05) was used

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ISSN: 1741-7015

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