Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study

Table 3 Sensitivity analysis of genetically predicted linoleic acid with ischemic heart disease and its risk factors using different analytic methods

Outcome	Methods	Odds ratio	95% CI	p	MR Egger intercept p
IHD	WM	0.98	0.96 to 1.01	0.09
IHD	MR Egger	0.97	0.94 to 1.01	0.10	0.32
Diabetes	WM	0.97	0.95 to 0.99	0.001
	MR Egger	0.95	0.93 to 0.98	0.001	0.12
		Beta	95% CI
LDL cholesterol	WM	− 0.034	− 0.039 to − 0.029	< 0.001
LDL cholesterol	MR Egger	− 0.035	− 0.055 to − 0.014	0.001	0.95
HDL cholesterol	WM	− 0.027	− 0.037 to − 0.016	0.01
HDL cholesterol	MR Egger	− 0.017	− 0.033 to − 0.002	0.03	0.12
Total cholesterol	WM	− 0.032	− 0.043 to − 0.020	0.01
Total cholesterol	MR Egger	−0.032	−0.054 to − 0.010	0.004	0.99
DBP	WM	0.006	− 0.001 to 0.013	0.07
DBP	MR Egger	− 0.002	− 0.018 to 0.015	0.85	0.15
SBP	WM	0.000	− 0.007 to 0.007	0.94
SBP	MR Egger	− 0.006	− 0.012 to 0.000	0.05	0.01
Reticulocyte count	WM	0.012	0.005 to 0.019	0.02
Reticulocyte count	MR Egger	0.009	− 0.022 to 0.040	0.56	0.76

DBP diastolic blood pressure, HDL high-density lipoprotein, LDL, low-density lipoprotein, SBP systolic blood pressure, WM weighted median

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