Table 4 Association of survival with potential prognostic factors available in at least one registry for resected pancreatic cancer estimated by adjusted Cox proportional hazard regression
Variable | The US | Belgium | The Netherlands | Slovenia | ||||
|---|---|---|---|---|---|---|---|---|
n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | n | HR (95% CI) | |
Resection margin | ||||||||
 Negative | – | – | – | – | 637 | 1.00 (reference) | 51 | 1.00 (reference) |
 Positive | – | – | – | – | 291 | 1.36 (1.12–1.65) | 34 | 1.54 (0.82–2.88) |
Hospital type | ||||||||
 Non-academic | – | – | 497 | 1.00 (reference) | 510 | 1.00 (reference) | – | – |
 Academic | – | – | 608 | 0.89 (0.77–1.03) | 472 | 0.79 (0.66–0.94) | – | – |
Tumor size | ||||||||
 ≤ 2 cm | 1490 | 1.00 (reference) | – | – | – | – | – | – |
 2–3 cm | 3146 | 1.23 (1.12–1.35) | – | – | – | – | – | – |
 3–4 cm | 2487 | 1.38 (1.25–1.52) | – | – | – | – | – | – |
 4–5 cm | 1229 | 1.60 (1.44–1.78) | – | – | – | – | – | – |
 > 5 cm | 938 | 1.56 (1.39–1.75) | – | – | – | – | – | – |
T stage (8th version) | ||||||||
 T1 | 1490 | 0.62 (0.57–0.68) | – | – | – | – | – | – |
 T2 | 5633 | 0.81 (0.76–0.87) | – | – | – | – | – | – |
 T3 | 2167 | 1.00 (reference) | – | – | – | – | – | – |
Positive LN number (continuous) | 9426 | 1.05 (1.04–1.06) | – | – | 974 | 1.07 (1.04–1.10) | – | – |
N stage (8th version) | ||||||||
 N0 (0 positive LNs) | 3180 | 1.00 (reference) | – | – | 280 | 1.00 (reference) | – | – |
 N1 (1–3 positive LNs) | 3885 | 1.42 (1.33–1.51) | – | – | 416 | 1.68 (1.33–2.13) | – | – |
 N2 (≥ 4 positive LNs) | 2244 | 1.84 (1.72–1.98) | – | – | 278 | 2.43 (1.89–3.12) | – | – |
Harvested LN number (continuous) | 9484 | 0.99 (0.99–0.99) | – | – | 959 | 0.99 (0.98–1.00) | – | – |
LN ratio (continuous) | 9138 | 2.60 (2.26–3.00) | – | – | 945 | 3.15 (2.05–4.84) | – | – |
ECOG score | ||||||||
 0 | – | – | 140 | 1.00 (reference) | – | – | – | – |
 1 | – | – | 662 | 0.96 (0.76–1.20) | – | – | – | – |
 ≥ 2 | – | – | 63 | 1.04 (0.73–1.47) | – | – | – | – |
Resection type | ||||||||
 Pancreatoduodenectomy | 7108 | 1.00 (reference) | – | – | 877 | 1.00 (reference) | – | – |
 Distal pancreatectomy | 1142 | 1.02 (0.92–1.14) | – | – | 88 | 1.33 (0.61–2.91) | – | – |
 Total pancreatectomy | 1102 | 1.07 (0.99–1.15) | – | – | 10 | 0.98 (0.36–2.65) | – | – |
Comorbidity | ||||||||
 Cardiovascular disease (yes v no) | – | – | – | – | 30/119 | 1.33 (0.69–2.57) | – | – |
 Hypertension (yes v no) | – | – | – | – | 39/110 | 1.01 (0.59–1.75) | – | – |
 Diabetes (yes v no) | – | – | – | – | 33/116 | 1.34 (0.76–2.38) | – | – |
 Pulmonary disease (yes v no) | – | – | – | – | 14/135 | 1.96 (0.88–4.36) | – | – |
Number of comorbidities | ||||||||
 0 | – | – | – | – | 52 | 1.00 (reference) | – | – |
 1 | – | – | – | – | 48 | 1.48 (0.84–2.62) | – | – |
 ≥ 2 | – | – | – | – | 49 | 1.86 (1.00–3.46) | – | – |