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Table 4 Type of long-term conditions and all-cause, cancer and vascular mortality over 7-year median follow-up: Cox’s regression analysis

From: Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort

Type of LTCs N = 500,769. Adjusted analyses* (missing values n = 12,045; 2.4%)
Hazard ratios (95% confidence intervals) for All-cause mortality Hazard ratios (95% confidence intervals) for cancer mortality Hazard ratios (95% confidence intervals) for vascular mortality
No cardiometabolic conditions 1 1 1
 1 LTC-cardiometabolic 1.19 (1.15–1.24) 1.04 (0.99–1.10) 1.79 (1.63–1.96)
 2 LTC-cardiometabolic 1.67 (1.58–1.77) 1.15 (1.06–1.24) 3.42 (3.06–3.82)
 3 LTC-cardiometabolic 2.52 (2.31–2.76) 1.23 (1.05–1.44) 7.31 (6.32–8.46)
 ≥ 4 LTC-cardiometabolic 3.20 (2.56–4.00) 1.67 (1.12–2.51) 8.20 (5.81–11.58)
No previous cancer 1 1 1
Presence history of Cancer 2.83 (2.71–2.95) 4.26 (4.06–4.47) 0.99 (0.87–1.13)
No non-cardiometabolic condition 1 1 1
 1 LTC (excluding cancer and cardiometabolic) 1.08 (1.04–1.12) 0.99 (0.95–1.04) 1.02 (0.94–1.11)
 2 LTCs (excluding cancer and cardiometabolic) 1.16 (1.10–1.22) 0.98 (0.92–1.05) 1.15 (1.03–1.29)
 3 LTCs (excluding cancer and cardiometabolic) 1.25 (1.16–1.35) 0.96 (0.86–1.07) 1.29 (1.10–1.52)
 4 LTCs (excluding cancer and cardiometabolic) 1.50 (1.36–1.67) 0.89 (0.75–1.05) 1.62 (1.31–1.99)
  1. Age as the time scale. LTC long-term conditions, cardiometabolic conditions hypertension, coronary heart disease, peripheral vascular disease, atrial fibrillation, diabetes, heart failure, stroke or transient ischaemic attack. *Adjusted for sex, socioeconomic status based on Townsend score, smoking status, alcohol status, body mass index and physical activity levels reported at baseline