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Table 5 The most impactful LTC combinations in stratified Cox’ regression analysis for mortality, for three different multimorbidity categories (based on LTC count)

From: Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort

Top 10 most impactful LTC combinations in each category of MM count

Adjusted hazard ratios for all-cause mortality, when compared to reference group—no LTCs; number of deaths

Category LTC count = 2; N = 95,226; total number of deaths N = 3555

Category 3: LTC count = 3, N = 43,120; total number of deaths N = 2213

Category 4: LTC count = ≥ 4, N = 26,125; total number of deaths N = 2025

Cancer + bronchiectasis

9.50 (3.56–25.36); N = 4 deaths

Cancer + HTN + CKD

12.27 (5.50–27.39); N = 6 deaths

Cancer + HTN + CHD + epilepsy

7.75 (2.48–24.21); N = 3 deaths

Cancer + epilepsy

9.06 (5.54–14.84); N = 16 deaths

HTN + CKD + diabetes

11.46 (6.29–20.89); N = 13 deaths

HTN + CKD + CHD + diabetes

7.16 (4.20–12.22); N = 17 deaths

Alcohol problem + HTN

7.49 (4.23–13.28); N = 12 deaths

Cancer + stroke/TIA + CHD

8.16 (3.05–21.84); N = 4 deaths

Cancer + HTN + CHD + connective tissue disorders

6.84 (3.40–13.76); N = 8 deaths

Alcohol problem + depression

5.71 (2.13–15.28); N = 4 deaths

HTN + CKD + CHD

8.13 (3.37–19.61); N = 5 deaths

Cancer + HTN + depression + COPD

6.60 (3.70–11.78); N = 12 deaths

Epilepsy + diabetes

5.60 (1.80–17.40); N = 3 deaths

Cancer + connective tissue disorders + osteoporosis

8.07 (3.34–19.47); N = 5 deaths

Cancer + HTN + diabetes + COPD

6.38 (3.81–10.70); N = 16 deaths

Cancer + COPD

5.54 (3.59–8.54); N = 22 deaths

Cancer + diabetes + CHD

8.01 (3.78–16.93); N = 7 deaths

Cancer + HTN + depression + osteoporosis

5.87 (2.19–15.69); N = 4 deaths

Cancer + peripheral vascular disease

5.14 (1.28–20.57); N = 2 deaths

CHD + COPD + diabetes

7.84 (3.23–19.01); N = 5 deaths

Cancer + HTN + stroke/TIA + COPD

5.38 (2.68–10.83); N = 8 deaths

Cancer + IBD

4.98 (2.58–9.59); N = 9 deaths

Cancer + HTN + IBD

5.59 (1.80–17.35); N = 3 deaths

Cancer + HTN + diabetes + connective tissue disorders

5.03 (1.61–15.68); N = 16 deaths

IBD + osteoporosis

4.88 (2.02–11.75); N = 5 deaths

Cancer + HTN + COPD

5.55 (3.06–10.06); N = 11 deaths

HTN + diabetes + depression + stroke/TIA

4.87 (2.90–8.18); N = 19 deaths

Osteoporosis + epilepsy

4.77 (1.53–14.80); N = 3 deaths

Cancer + HTN + stroke/TIA

5.43 (3.62–8.14); N = 24 deaths

HTN + CHD + diabetes + stroke/TIA

4.64 (3.50–6.14); N = 63 deaths

  1. All predictors entered individually in separate models using zero LTC group as the reference category and age as time scale; adjusted for sex, socioeconomic status based on Townsend score, smoking, alcohol consumption, body mass index and physical activity levels at baseline
  2. LTC long-term condition, HTN hypertension, COPD chronic obstructive pulmonary disease, TIA transient ischaemic attack, CHD coronary heart disease, CKD chronic kidney disease, IBD inflammatory bowel disease. Connective tissue disorders myositis/myopathy, systemic lupus erythematosus, Sjogren’s syndrome/sicca syndrome, dermatopolymyositis, scleroderma/systemic sclerosis, rheumatoid arthritis, psoriatic arthropathy, dermatomyositis, polymyositis, polymyalgia rheumatica, coeliac disease
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BMC Medicine

ISSN: 1741-7015

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