Fig. 1

Flow diagram of patient inclusion and follow-up. *Patients failing to meet the criteria for continue, switch, or add had either more complex therapy changes such as adding or switching multiple medications in the 1-year follow-up period, or had reduced adherence to any of the study medications. †This time window was selected to provide an outcome HbA1c measurement in the same time period as the response HbA1c in those switching or adding medications. CPRD Clinical Practice Research Datalink