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Table 6 Odds ratios (95% confidence intervals) of somatic diseases/disorders (lifetime prevalence) regressed on immune-mediated classes, men and women

From: A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study

  Neutral class Resilient class Atopic class Mixed class ACE class
Men
 Ulcer 1 (ref.) 1.6 (1.1–2.3) 1.0 (0.4–2.1) 0.7 (0.3–1.6) 0.7 (0.3–2.1)
 Irritable bowel syndrome 1 (ref.) 1.0 (0.5–2.1) 3.0 (1.3–7.0) 2.5 (1.1–5.6) 1.1 (0.3–4.8)
 Cystitis 1 (ref.) 0.7 (0.4–1.3) 3.2 (1.8–5.7) 3.3 (1.9–5.5) 1.5 (0.6–3.6)
 Acne 1 (ref.) 0.7 (0.5–1.1) 1.4 (0.8–2.5) 1.8 (1.1–2.8) 0.7 (0.3–1.7)
 Psoriasis 1 (ref.) 0.7 (0.4–1.1) 0.3 (0.1–1.2) 1.3 (0.7–2.5) 1.2 (0.5–2.9)
 Migraine 1 (ref.) 1.1 (0.7–1.6) 1.8 (1.1–3.2) 2.3 (1.5–3.6) 1.3 (0.6–2.6)
Women
 Ulcer 1 (ref.) 1.3 (0.8–2.1) 1.5 (0.8–2.9) 1.4 (0.8–2.5) 3.1 (1.8–5.4)
 Irritable bowel syndrome 1 (ref.) 1.5 (0.9–2.4) 2.0 (1.1–3.8) 2.9 (1.8–4.8) 3.7 (2.1–6.6)
 Cystitis 1 (ref.) 1.0 (0.8–1.2) 2.1 (1.5–2.8) 1.9 (1.5–2.5) 2.2 (1.5–3.0)
 Acne 1 (ref.) 0.9 (0.6–1.3) 1.1 (0.6–1.7) 1.5 (1.0–2.2) 1.8 (1.1–2.8)
 Psoriasis 1 (ref.) 0.9 (0.5–1.5) 1.0 (0.5–2.1) 0.9 (0.5–1.8) 1.6 (0.8–3.2)
 Migraine 1 (ref.) 0.9 (0.7–1.2) 1.7 (1.2–2.4) 1.2 (0.9–1.7) 1.2 (0.8–1.8)
  1. ACE adverse childhood experiences