Fig. 2

Time-dependent associations between a 10% increase in the FI and mortality in single responders. Time-dependent effects of FI for all-cause, CVD, and respiratory-related mortality in both men and women were observed, with relatively greater HRs at younger ages and effect sizes decreasing with increasing age at FI assessment for all the causes. All models were adjusted for BMI, years of education, and tobacco use status, and additionally adjusted for history of CVD or respiratory diseases in corresponding cause-specific mortality analysis, and were fitted as a function of age at FI assessment