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Table 2 Supportive care and treatment in children with severe malaria according to AKI status

From: Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

  Severe malarial anemia (n = 219) Cerebral malaria (n = 260)
No AKI (n = 164) AKI (n = 55) p value No AKI (n = 147) AKI (n = 113) p value
Supportive care
 Oxygen 22 (6.7) 7 (12.7) 0.160 71 (48.3) 76 (67.3) 0.002
 Antipyretics 161 (98.2) 53 (96.4) 0.437 138 (93.9) 104 (92.0) 0.562
Medications
 Quinine 127 (77.4) 44 (80.0) 0.691 131 (89.1) 99 (87.6) 0.707
 Artesunate/artemether 55 (33.5) 16 (29.1) 0.619 43 (29.3) 39 (34.5) 0.420
 Anticonvulsants 1 (0.6) 2 (3.6) 0.156 109 (74.2) 96 (85.0) 0.034
 Furosemide 32 (19.5) 11 (20.0) 0.937 9 (6.1) 26 (23.0) < 0.0001
 Bolus dextrose 28 (17.1) 28 (50.9) < 0.0001 132 (89.8) 91 (80.5) 0.034
Intravenous fluids 12 (7.3) 5 (9.1) 0.671 24 (16.3) 32 (28.3) 0.020
 0.9% saline 10 (6.1) 4 (7.3) 0.754 18 (12.2) 24 (21.2) 0.051
 Ringer’s lactate 0 (0.0) 0 (0.0) 2 (1.4) 4 (3.5) 0.246
 10% dextrose 0 (0.0) 0 (0.0) 4 (2.7) 2 (1.8) 0.700
 Bicarbonate 0 (0.0) 0 (0.0) 0 (0.0) 1 (0.9) 0.435
 Darrow’s 0 (0.0) 1 (1.8) 0.251 1 (0.7) 0 (0.0) 1.000
 Albumin 2 (1.2) 0 (0.0) 1.000 2 (1.4) 4 (3.5) 0.408
Blood transfusion 164 (100.0) 55 (100.0) 68 (46.3) 81 (71.7) < 0.0001
  1. Data presented as n (%) and compared using Pearson’s chi-square or Fisher’s exact, as appropriate