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Table 2 Supportive care and treatment in children with severe malaria according to AKI status

From: Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

 

Severe malarial anemia (n = 219)

Cerebral malaria (n = 260)

No AKI (n = 164)

AKI (n = 55)

p value

No AKI (n = 147)

AKI (n = 113)

p value

Supportive care

 Oxygen

22 (6.7)

7 (12.7)

0.160

71 (48.3)

76 (67.3)

0.002

 Antipyretics

161 (98.2)

53 (96.4)

0.437

138 (93.9)

104 (92.0)

0.562

Medications

 Quinine

127 (77.4)

44 (80.0)

0.691

131 (89.1)

99 (87.6)

0.707

 Artesunate/artemether

55 (33.5)

16 (29.1)

0.619

43 (29.3)

39 (34.5)

0.420

 Anticonvulsants

1 (0.6)

2 (3.6)

0.156

109 (74.2)

96 (85.0)

0.034

 Furosemide

32 (19.5)

11 (20.0)

0.937

9 (6.1)

26 (23.0)

< 0.0001

 Bolus dextrose

28 (17.1)

28 (50.9)

< 0.0001

132 (89.8)

91 (80.5)

0.034

Intravenous fluids

12 (7.3)

5 (9.1)

0.671

24 (16.3)

32 (28.3)

0.020

 0.9% saline

10 (6.1)

4 (7.3)

0.754

18 (12.2)

24 (21.2)

0.051

 Ringer’s lactate

0 (0.0)

0 (0.0)

–

2 (1.4)

4 (3.5)

0.246

 10% dextrose

0 (0.0)

0 (0.0)

–

4 (2.7)

2 (1.8)

0.700

 Bicarbonate

0 (0.0)

0 (0.0)

–

0 (0.0)

1 (0.9)

0.435

 Darrow’s

0 (0.0)

1 (1.8)

0.251

1 (0.7)

0 (0.0)

1.000

 Albumin

2 (1.2)

0 (0.0)

1.000

2 (1.4)

4 (3.5)

0.408

Blood transfusion

164 (100.0)

55 (100.0)

–

68 (46.3)

81 (71.7)

< 0.0001

  1. Data presented as n (%) and compared using Pearson’s chi-square or Fisher’s exact, as appropriate