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Table 2 Univariate and multivariate Cox analysis of OS in the training cohort (n = 352)

From: Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma

  Univariate analysis   Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Sex (female/male) 0.934 (0.611, 1.428) 0.75   
Age, years 1.007 (0.991, 1.024) 0.38   
HBsAg (yes/no) 0.915 (0.590, 1.419) 0.69   
HBcAb (yes/no) 0.664 (0.405, 1.088) 0.12   
Anti-HCV (yes/no) 1.671 (0.234, 11.951) 0.61   
Bilirubin, μmol/L 0.987 (0.961, 1.014) 0.36   
ALT, IU/L 1.002 (1.000, 1.004) 0.12   
Albumin, g/L 0.738 (0.526, 1.035) 0.08   
AFP, ng/mL 1.000 (1.000, 1.000) 0.19   
GGT, U/L 1.002 (1.001, 1.004) < 0.001 1.002 (1.000, 1.004) 0.01
Liver cirrhosis (yes/no) 1.461 (0.919, 2.319) 0.11   
Tumor diameter, cm 1.153 (1.107, 1.202) < 0.001 1.100 (1.046, 1.156) < 0.001
Tumor number 1.259 (1.004, 1.583) 0.046 1.266 (0.976, 1.643) 0.08
Microvascular invasion (yes/no) 1.362 (1.065, 1.767) 0.02 1.211 (0.995, 1.599) 0.09
Lymphoid metastasis (yes/no) 1.833 (0.256, 13.108) 0.55   
Tumor differentiation (Edmondson-Steiner grade I-II/III-IV) 1.753 (1.232, 2.494) 0.002 1.819 (1.268, 2.610) 0.001
Occlusion time, min 1.028 (1.011, 1.045) < 0.001 1.013 (0.996, 1.031) 0.14
TRIS 12.197 (3.835, 38.791) < 0.001 4.606 (1.335, 15.89) 0.02
  1. HBsAg hepatitis B surface antigen, HBcAb hepatitis B core antibody, HCV hepatitis C virus, AFP α-fetoprotein, ALT alanine aminotransferase, GGT γ-glutamyl transferase, AFP alpha fetoprotein, TRIS tissue-related immune signature
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