Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma

Table 2 Univariate and multivariate Cox analysis of OS in the training cohort (n = 352)

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Sex (female/male)	0.934 (0.611, 1.428)	0.75
Age, years	1.007 (0.991, 1.024)	0.38
HBsAg (yes/no)	0.915 (0.590, 1.419)	0.69
HBcAb (yes/no)	0.664 (0.405, 1.088)	0.12
Anti-HCV (yes/no)	1.671 (0.234, 11.951)	0.61
Bilirubin, μmol/L	0.987 (0.961, 1.014)	0.36
ALT, IU/L	1.002 (1.000, 1.004)	0.12
Albumin, g/L	0.738 (0.526, 1.035)	0.08
AFP, ng/mL	1.000 (1.000, 1.000)	0.19
GGT, U/L	1.002 (1.001, 1.004)	< 0.001	1.002 (1.000, 1.004)	0.01
Liver cirrhosis (yes/no)	1.461 (0.919, 2.319)	0.11
Tumor diameter, cm	1.153 (1.107, 1.202)	< 0.001	1.100 (1.046, 1.156)	< 0.001
Tumor number	1.259 (1.004, 1.583)	0.046	1.266 (0.976, 1.643)	0.08
Microvascular invasion (yes/no)	1.362 (1.065, 1.767)	0.02	1.211 (0.995, 1.599)	0.09
Lymphoid metastasis (yes/no)	1.833 (0.256, 13.108)	0.55
Tumor differentiation (Edmondson-Steiner grade I-II/III-IV)	1.753 (1.232, 2.494)	0.002	1.819 (1.268, 2.610)	0.001
Occlusion time, min	1.028 (1.011, 1.045)	< 0.001	1.013 (0.996, 1.031)	0.14
TRIS	12.197 (3.835, 38.791)	< 0.001	4.606 (1.335, 15.89)	0.02

HBsAg hepatitis B surface antigen, HBcAb hepatitis B core antibody, HCV hepatitis C virus, AFP α-fetoprotein, ALT alanine aminotransferase, GGT γ-glutamyl transferase, AFP alpha fetoprotein, TRIS tissue-related immune signature

ISSN: 1741-7015