|
Individuals
|
N
|
RRR
|
Lower
|
Upper
|
P value
|
Test for heterogeneity
|
P value for interaction
|
---|
I2 (%)
|
χ
2
|
P value
| |
---|
All-cause mortality
|
3,887,585
|
28
| | | | | | | | |
Age (years)
| | | | | | | | | |
0.97
|
< 60
|
2,517,958
|
17
|
1.10
|
1.01
|
1.21
|
0.03
|
64.60
|
45.24
|
< 0.001
| |
≥ 60
|
268,044
|
7
|
1.10
|
1.04
|
1.18
|
< 0.001
|
0.00
|
3.00
|
0.81
| |
Others
|
1,101,583
|
4
|
1.19
|
0.91
|
1.57
|
0.21
|
84.30
|
19.05
|
< 0.001
| |
Location
| | | | | | | | | |
0.63
|
Asia
|
1944.650
|
8
|
1.12
|
1.03
|
1.21
|
0.05
|
56.00
|
15.89
|
0.03
| |
Western Europe
|
347,906
|
8
|
1.18
|
0.93
|
1.50
|
0.18
|
76.40
|
29.69
|
< 0.001
| |
North America
|
1,572,948
|
8
|
1.10
|
1.08
|
1.12
|
< 0.001
|
0.00
|
4.33
|
0.74
| |
Others
|
22,081
|
4
|
0.96
|
0.73
|
1.26
|
0.77
|
32.80
|
4.47
|
0.22
| |
Follow-up years
| | | | | | | | | |
0.64
|
< 10
|
908,252
|
9
|
1.12
|
1.02
|
1.22
|
0.02
|
38.00
|
12.91
|
0.12
| |
≥ 10
|
2,979,333
|
19
|
1.13
|
1.06
|
1.21
|
< 0.001
|
66.2
|
53.32
|
< 0.001
| |
Publication years
| | | | | | | | | |
0.55
|
≤ 2000
|
95,532
|
9
|
1.1
|
0.9
|
1.4
|
0.5
|
64.50
|
22.51
|
< 0.001
| |
2001–2009
|
1,381,865
|
5
|
1.3
|
1.0
|
1.6
|
< 0.001
|
81.50
|
21.60
|
< 0.001
| |
≥ 2010
|
2,410,188
|
14
|
1.1
|
1.0
|
1.2
|
< 0.001
|
39.8
|
21.59
|
0.06
| |
Method of diabetes ascertainment
| | | | | | | | | |
0.24
|
KDM
|
2,486,016
|
18
|
1.17
|
1.07
|
1.26
|
< 0.001
|
74.2
|
65.97
|
< 0.001
| |
NDM
|
590,506
|
6
|
1.05
|
0.90
|
1.21
|
0.20
|
32.10
|
7.36
|
0.6
| |
KDM, NDM
|
1,363,765
|
9
|
1.05
|
0.97
|
1.15
|
0.3
|
16.40
|
9.56
|
< 0.001
| |
Treated diabetes
|
NA
| | | | | | | | | |
Cancer mortality
|
4,482,501
|
14
| | | | | | | | |
Age (years)
| | | | | | | | | |
0.92
|
< 60
|
3,361,850
|
12
|
1.01
|
0.95
|
1.07
|
0.75
|
0.00
|
10.69
|
0.47
| |
≥ 60
|
66,820
|
1
|
1.02
|
0.88
|
1.18
|
0.81
|
NA
|
0.00
|
NA
| |
Others
|
52,655
|
1
|
1.04
|
0.99
|
1.09
|
0.17
|
NA
|
0.72
|
NA
| |
Location
| | | | | | | | | |
0.56
|
Asia
|
2,795,136
|
8
|
1.01
|
0.96
|
1.08
|
0.65
|
0.00
|
5.33
|
0.62
| |
Western Europe
|
276,141
|
3
|
0.94
|
0.58
|
1.51
|
0.80
|
53.50
|
4.30
|
0.12
| |
North America
|
1,411,224
|
3
|
1.04
|
0.99
|
1.09
|
0.15
|
0.00
|
0.03
|
0.98
| |
Others
|
NA
| | | | | | | | | |
Follow-up years
| | | | | | | | | |
0.47
|
< 10
|
881,061
|
3
|
1.08
|
0.94
|
1.23
|
0.29
|
0.00
|
1.45
|
0.49
| |
≥ 10
|
3,601,440
|
11
|
1.02
|
0.98
|
1.06
|
0.32
|
0.00
|
9.18
|
0.52
| |
Publication years
| | | | | | | | | | |
≤ 2000
|
5131
|
1
|
1.11
|
0.31
|
3.94
|
0.87
|
NA
|
0.00
|
NA
|
0.73
|
2001–2009
|
1,327,437
|
2
|
1.05
|
0.91
|
1.20
|
0.50
|
5.10
|
1.05
|
0.31
| |
≥ 2010
|
3,149,933
|
11
|
1.02
|
0.98
|
1.06
|
0.30
|
0.00
|
9.99
|
0.44
| |
Method of diabetes ascertainment
| | | | | | | | | |
0.72
|
KDM
|
2,094,903
|
9
|
1.03
|
0.90
|
1.19
|
0.65
|
77.90
|
36.21
|
< 0.001
| |
NDM
|
557,524
|
2
|
1.07
|
0.96
|
1.18
|
0.22
|
0.00
|
0.04
|
0.84
| |
KDM, NDM
|
2,369,318
|
4
|
1.03
|
0.99
|
1.08
|
0.16
|
0.00
|
1.16
|
0.764
| |
Treated diabetes
|
18,280
|
1
|
0.99
|
0.56
|
1.74
|
0.96
|
NA
|
0
|
NA
| |
CVD mortality
|
2,067,486
|
23
| | | | | | | | |
Age (years)
| | | | | | | | | |
0.91
|
< 60
|
867,999
|
18
|
1.26
|
1.01
|
1.56
|
0.04
|
72.20
|
61.20
|
< 0.001
| |
≥ 60
|
106,601
|
3
|
1.12
|
0.98
|
1.29
|
0.10
|
5.70
|
2.12
|
0.35
| |
Others
|
1,092,886
|
2
|
1.53
|
0.77
|
3.04
|
0.23
|
96.60
|
29.05
|
< 0.001
| |
Location
| | | | | | | | | |
0.64
|
Asia
|
159,835
|
6
|
1.08
|
0.96
|
1.22
|
0.20
|
0.00
|
4.95
|
0.42
| |
Western Europe
|
460,756
|
8
|
1.49
|
1.17
|
1.90
|
< 0.001
|
58.70
|
16.96
|
0.02
| |
North America
|
1,415,878
|
6
|
1.33
|
1.03
|
1.72
|
0.03
|
88.20
|
42.22
|
< 0.001
| |
Others
|
31,017
|
3
|
1.12
|
0.75
|
1.67
|
0.57
|
0.00
|
0.53
|
0.77
| |
Follow-up years
| | | | | | | | | |
0.38
|
< 10
|
433,100
|
6
|
1.08
|
0.96
|
1.22
|
0.19
|
0.00
|
4.13
|
0.53
| |
≥ 10
|
1,634,386
|
17
|
1.35
|
1.13
|
1.62
|
< 0.001
|
83.00
|
93.96
|
< 0.001
| |
Publication years
| | | | | | | | | |
0.13
|
≤ 2000
|
54,288
|
4
|
1.36
|
0.75
|
2.47
|
0.31
|
79.10
|
14.33
|
< 0.001
| |
2001–2009
|
142,444
|
6
|
1.63
|
1.04
|
2.57
|
0.03
|
83.50
|
30.31
|
< 0.001
| |
≥ 2010
|
1,870,754
|
13
|
1.09
|
1.06
|
1.12
|
< 0.001
|
0.00
|
4.62
|
0.97
| |
Method of diabetes ascertainment
| | | | | | | | | |
0.53
|
KDM
|
1,876,261
|
11
|
1.20
|
1.02
|
1.42
|
0.03
|
85.10
|
66.94
|
< 0.001
| |
NDM
|
42,944
|
3
|
1.40
|
0.84
|
2.35
|
0.20
|
74.50
|
7.85
|
0.02
| |
KDM, NDM
|
152,371
|
11
|
1.31
|
0.95
|
1.82
|
0.10
|
73.10
|
37.23
|
< 0.001
| |
Treated diabetes
|
NA
| | | | | | | | | |
CHD mortality
|
2,050,929
|
23
| | | | | | | | |
Age (years)
| | | | | | | | | |
0.88
|
< 60
|
864,790
|
15
|
1.52
|
1.22
|
1.90
|
< 0.001
|
39.20
|
23.02
|
0.06
| |
≥ 60
|
89,838
|
4
|
1.68
|
1.22
|
2.30
|
< 0.001
|
0.00
|
2.69
|
0.44
| |
Others
|
1,096,301
|
4
|
1.65
|
0.90
|
3.04
|
0.11
|
89.70
|
29.18
|
< 0.001
| |
Location
| | | | | | | | | |
0.88
|
Asia
|
692,384
|
5
|
1.53
|
0.99
|
2.38
|
0.06
|
61.10
|
10.29
|
0.04
| |
Western Europe
|
242,624
|
8
|
1.86
|
1.42
|
2.45
|
< 0.001
|
41.60
|
11.98
|
0.10
| |
North America
|
1,113,375
|
9
|
1.17
|
1.13
|
1.22
|
< 0.001
|
0.00
|
7.26
|
0.51
| |
Others
|
2546
|
1
|
3.11
|
0.79
|
12.23
|
0.11
|
NA
|
0.00
|
NA
| |
Follow-up years
| | | | | | | | | |
0.17
|
< 10
|
606,561
|
6
|
1.23
|
0.85
|
1.79
|
0.23
|
27.20
|
6.87
|
0.27
| |
≥ 10
|
1,371,125
|
14
|
1.75
|
1.33
|
2.31
|
0.00
|
78.50
|
60.43
|
< 0.001
| |
Others
|
73,243
|
3
|
1.38
|
0.95
|
2.02
|
0.10
|
0.00
|
0.86
|
0.65
| |
Publication years
| | | | | | | | | |
0.20
|
≤ 2000
|
111,122
|
10
|
1.66
|
1.21
|
2.27
|
0.00
|
41.90
|
15.49
|
0.08
| |
2001–2009
|
118,915
|
6
|
1.84
|
1.25
|
2.71
|
0.00
|
32.80
|
7.44
|
0.19
| |
≥ 2010
|
1,820,892
|
7
|
1.30
|
1.12
|
1.52
|
0.00
|
41.00
|
10.17
|
0.12
| |
Method of diabetes ascertainment
| | | | | | | | | |
0.85
|
KDM
|
1,457,769
|
14
|
1.52
|
1.20
|
1.92
|
0.00
|
78.10
|
59.23
|
< 0.001
| |
NDM
|
119,825
|
4
|
1.90
|
0.98
|
3.70
|
0.06
|
70.70
|
10.26
|
0.02
| |
KDM, NDM
|
543,435
|
7
|
1.34
|
1.14
|
1.57
|
0.00
|
0.00
|
5.42
|
0.49
| |
Treated diabetes
|
NA
| | | | | | | | | |
Stroke mortality
|
2,292,387
|
15
| | | | | | | | |
Age (years)
| | | | | | | | | |
0.71
|
< 60
|
1,078,421
|
10
|
1.12
|
0.98
|
1.28
|
0.11
|
0.00
|
7.36
|
0.60
| |
≥ 60
|
105,674
|
2
|
1.06
|
0.85
|
1.33
|
0.61
|
0.00
|
0.03
|
0.86
| |
Others
|
1,108,292
|
3
|
1.07
|
0.99
|
1.15
|
0.08
|
0.00
|
1.67
|
0.43
| |
Location
| | | | | | | | | |
0.42
|
Asia
|
764,335
|
7
|
1.11
|
0.97
|
1.26
|
0.12
|
0.00
|
5.04
|
0.54
| |
Western Europe
|
132,562
|
5
|
1.36
|
0.97
|
1.90
|
0.07
|
0.00
|
1.60
|
0.81
| |
North America
|
1,392,944
|
2
|
1.06
|
0.98
|
1.13
|
0.13
|
0.00
|
0.08
|
0.78
| |
Others
|
2546
|
1
|
0.46
|
0.03
|
7.76
|
0.59
|
NA
|
0.00
|
NA
| |
Follow-up years
| | | | | | | | | |
0.58
|
< 10
|
903,575
|
4
|
1.12
|
0.96
|
1.30
|
0.14
|
0.00
|
2.62
|
0.45
| |
≥ 10
|
1,388,812
|
11
|
1.07
|
1.00
|
1.14
|
0.06
|
0.00
|
6.48
|
0.77
| |
Others
|
NA
| | | | | | | | | |
Publication years
| | | | | | | | | |
0.25
|
≤ 2000
|
67,444
|
5
|
1.39
|
0.90
|
2.14
|
0.14
|
0.00
|
2.67
|
0.62
| |
2001–2009
|
101,874
|
3
|
1.09
|
0.63
|
1.91
|
0.75
|
23.90
|
2.63
|
0.27
| |
≥ 2010
|
2,123,069
|
7
|
1.07
|
1.00
|
1.14
|
0.04
|
0.00
|
2.66
|
0.85
| |
Method of diabetes ascertainment
| | | | | | | | | |
0.27
|
KDM
|
1,720,989
|
10
|
1.06
|
1.00
|
1.13
|
0.07
|
0.00
|
8.36
|
0.50
| |
NDM
|
61,368
|
2
|
1.37
|
0.70
|
2.66
|
0.36
|
24.80
|
1.33
|
0.25
| |
KDM, NDM
|
532,544
|
4
|
1.18
|
0.98
|
1.42
|
0.09
|
0.40
|
3.01
|
0.39
| |
Treated diabetes
|
NA
| | | | | | | | | |
- Abbreviations: N number of studies, NA not available, CVD cardiovascular disease, CHD coronary heart disease