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Table 1 Trial treatment arms

From: Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration

Age

WHO Plan C

Slow arm

No shock

With WHO shock*

No shock

With shock

< 12 months

Step 1

30 ml/kg over 1 h

Step 2

70 ml/kg over 5 h

Resuscitate:

Up to 3 × 20 ml/kg bolus then to step 2

70 ml/kg over 5 h

100 ml/kg over 8 h

100 ml/kg over 8 h with

No additional boluses

> 12 months

Step 1

30 ml/kg over 30 min

Step 2

70 ml/kg over 2.5 h

Resuscitate:

Up to 3 × 20 ml/kg bolus then to step 2

70 ml/kg over 2.5 h

100 ml/kg over 8 h

100 ml/kg over 8 h

No additional boluses

  1. *Shock defined as presence of all three of the following: Weak and fast pulse, temperature gradient and prolonged capillary refill time > 3 s (10)