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Fig. 6 | BMC Medicine

Fig. 6

From: GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

Fig. 6

a–d ROC graphical plot that illustrates the diagnostic ability of the binary classifier NAFLD (cases and controls) and NAS score (above and below 5) using weighted GRS score of ten previously published SNPs (GRS-10, see “Results”). The sensitivity and specificity and AUC measures for each plot are also shown. a ROC curve for NAFLD-1106 cases and 8571 controls. b ROC curve for NAS score (79 cases above NAS score ≥ 5 versus 156 controls with score < 5). c Adding SNP rs5748926 near IL17RA improved the ROC curves for NAS score (GRS_11); difference between areas 0.035 (SE = 0.012, p = 0.004). d Distribution of quantiles of weighted 10-SNP GRS in NAFLD (cases and controls) and NAS score (above and below 5); percentage of NAFLD risk increases by increasing GRS quantiles; for NAFLD (cases and controls) from 17% in Q1 to 36% in Q4 (OR = 2.16, 95% CI = 1.81–2.58, p < 0.0001); for NAS score above 5 (defined as case) from 10% in Q1 to 43% in Q4 (OR = 8.50, 95% CI 3.45–20.96). The weighted 10-SNP GRS was calculated by multiplying the sum of the number of risk alleles (0, 1, 2) with the allele-specific effect sizes (beta coefficients) obtained from previous publications (see “Methods”)

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