Skip to main content

Advertisement

Table 1 Laboratory, clinical, and histologic characteristics of NAFLD patients included in the case-only association analyses. All individuals were of European ancestry

From: GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

  Pediatrics Adult Overall
Histologic characteristic—NAS score (0–8) † 4.01(SD 1.58) 3.45(SD 1.74) 3.78(SD 1.76)
NAS score ≥ 5 43/107 (40%) 36/128 (28%) 79/235 (34%)
Histologic characteristic—fibrosis score (0–4) † 0.71(SD 0.67) 1.01(SD 1.26) 0.88(SD 1.06)
ALT U/L‡ 40 (37–45) 63 (59–67) 53 (49–58)
AST U/L‡ 45 (42–48) 39 (37–41) 41 (39–43)
Presence of cirrhosis N = 0 N = 64 N = 64
Presence of hepatocellular CA N = 0 N = 15 N = 15
  1. †NAS and fibrosis score were available for 235 subjects (107 pediatrics and 128 adult subjects). For histologic score, mean and standard deviation is shown
  2. ‡ ALT and AST lab values were available for 1075 of cases. Medians and 95% CI of medians are shown