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Table 1 Laboratory, clinical, and histologic characteristics of NAFLD patients included in the case-only association analyses. All individuals were of European ancestry

From: GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

 

Pediatrics

Adult

Overall

Histologic characteristic—NAS score (0–8) †

4.01(SD 1.58)

3.45(SD 1.74)

3.78(SD 1.76)

NAS score ≥ 5

43/107 (40%)

36/128 (28%)

79/235 (34%)

Histologic characteristic—fibrosis score (0–4) †

0.71(SD 0.67)

1.01(SD 1.26)

0.88(SD 1.06)

ALT U/L‡

40 (37–45)

63 (59–67)

53 (49–58)

AST U/L‡

45 (42–48)

39 (37–41)

41 (39–43)

Presence of cirrhosis

N = 0

N = 64

N = 64

Presence of hepatocellular CA

N = 0

N = 15

N = 15

  1. †NAS and fibrosis score were available for 235 subjects (107 pediatrics and 128 adult subjects). For histologic score, mean and standard deviation is shown
  2. ‡ ALT and AST lab values were available for 1075 of cases. Medians and 95% CI of medians are shown