Fig. 4
The IGF1 signaling pathway is related to hypertension and cardiovascular risk. a Box plots show mRNA levels in leukocytes of patients within IGF1hi or IGF1low groups. b Correlation matrix shows Spearman’s R values in color, as indicated the color key code, in patients with normal blood pressure (BP) or hypertension. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. c Heatmap shows individual components related to IGF1 signaling of 60 RA patients. Unsupervised clustering analysis was done using the Spearman’s correlation-based distances and Ward2 linkage and formed 4 clusters. The table represents the mean and standard deviation of the parameters by cluster. The difference between clusters 1–3 and 4 was calculated with the t-test. RQ, relative quantity; MTX, methotrexate; TNFi, tumor necrosis factor inhibitors; DMARD, disease modifying anti-rheumatic drugs; DAS28, disease activity score with an assessment of 28 joints; DD, disease duration