Antibody | Month 3 IgG levels | Age (5–17 months) | Site (Manhiça) | Baseline IgG levels | WAZ | Vaccine (RTS,S) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Antigen | OR | p | OR | p | OR | p | OR | p | OR | p | OR | p |
Group i antigens | ||||||||||||
 MSP142 3D7 | 1.11 (0.7; 1.74) | 0.65 |  |  | 0.18 (0.08; 0.39) | < 0.001 | 1.47 (0.96; 2.28) | 0.08 |  |  |  |  |
 MSP142 FVO | 0.87 (0.57; 1.29) | 0.48 | 0.5 (0.23; 1.04) | 0.07 | 0.13 (0.05; 0.29) | < 0.001 | 1.47 (1.02;2.15) | 0.04 | 0.78 (0.56; 1.08) | 0.13 | 0.59 (0.28; 1.2) | 0.15 |
 EXP1 | 0.8 (0.47; 1.33) | 0.39 |  |  | 0.19 (0.08; 0.43) | < 0.001 | 1.94 (1.24; 3.12) | 0.005 | 0.75 (0.54; 1.05) | 0.1 | 0.53 (0.25; 1.1) | 0.09 |
 AMA1 FVO | 1.6 (1.15; 2.27) | 0.006 |  |  | 0.13 (0.06; 0.25) | < 0.001 |  |  |  |  |  |  |
 AMA1 3D7 | 0.98 (0.51; 1.83) | 0.94 |  |  | 0.14 (0.07; 0.28) | < 0.001 | 1.54 (0.93; 2.67) | 0.1 | 0.78 (0.56; 1.08) | 0.14 | 0.56 (0.27; 1.15) | 0.12 |
Group ii antigens | ||||||||||||
 pTRAMP | 1.01 (0.51; 2.03) | 0.98 | 0.42 (0.2; 0.85) | 0.02 | 0.12 (0.06; 0.25) | < 0.001 | 2.18 (1.16; 4.21) | 0.02 |  |  | 0.54 (0.26; 1.11) | 0.1 |
 EBA175 R2(F2) | 0.96 (0.56; 1.64) | 0.89 | 0.49 (0.24; 0.98) | 0.047 | 0.09 (0.04; 0.18) | < 0.001 |  |  |  |  |  |  |
 PfRH1 | 1.58 (0.79; 3.19) | 0.2 | 0.4 (0.18; 0.83) | 0.02 | 0.11 (0.05; 0.23) | < 0.001 |  |  | 0.79 (0.56; 1.09) | 0.15 |  |  |
 MSP3 3D7 | 1.32 (0.77; 2.3) | 0.32 | 0.51 (0.25; 1.02) | 0.06 | 0.1 (0.05; 0.2) | < 0.001 |  |  |  |  |  |  |
 Var2csa DBL3–4 | 1.03 (0.5;2.1) | 0.94 | 0.5 (0.21; 1.13) | 0.1 | 0.09 (0.04; 0.2) | < 0.001 |  |  |  |  |  |  |
 p41 | 1.41 (0.64; 3.16) | 0.4 | 0.46 (0.22; 0.94) | 0.04 | 0.1 (0.05; 0.19) | < 0.001 |  |  |  |  |  |  |
 MSP2 FL Dd2 | 0.89 (0.47; 1.61) | 0.71 |  |  | 0.25 (0.11; 0.57) | 0.001 | 2.15 (1.31; 3.67) | 0.003 | 0.76 (0.54; 1.06) | 0.11 | 0.52 (0.25; 1.07) | 0.08 |
 MSP2 FL CH150 | 1.02 (0.57; 1.83) | 0.96 |  |  | 0.25 (0.11; 0.58) | 0.001 | 2.05 (1.31; 3.29) | 0.002 | 0.76 (0.54; 1.06) | 0.11 | 0.44 (0.2; 0.92) | 0.03 |
 MSP1 Bl2 hybrid | 1.11 (0.68; 1.83) | 0.67 | 0.5 (0.24; 0.98) | 0.049 | 0.09 (0.04; 0.19) | < 0.001 |  |  |  |  |  |  |
 MSP3 3C | 1.22 (0.74; 2.01) | 0.43 | 0.41 (0.19; 0.84) | 0.02 | 0.1 (0.05; 0.22) | < 0.001 | 1.67 (0.94; 2.99) | 0.08 |  |  | 0.55 (0.27; 1.14) | 0.11 |
 PfRH2 b240 | 1.03 (0.49; 2.18) | 0.94 | 0.49 (0.24; 0.98) | 0.049 | 0.09 (0.04; 0.19) | < 0.001 |  |  |  |  |  |  |
 LSA1 | 0.88 (0.51; 1.49) | 0.64 | 0.5 (0.24; 0.99) | 0.051 | 0.09 (0.04; 0.18) | < 0.001 |  |  |  |  |  |  |
 MSP1 Bl2 PA17 | 0.96 (0.53; 1.7) | 0.89 | 0.5 (0.24; 0.98) | 0.048 | 0.09 (0.04; 0.18) | < 0.001 |  |  |  |  |  |  |
 Var2csa DBL1–2 | 0.9 (0.37; 2.27) | 0.82 |  |  | 0.14 (0.07; 0.29) | < 0.001 | 2.06 (1.01; 4.26) | 0.047 |  |  | 0.57 (0.28; 1.16) | 0.12 |
 CyRPA | 1.81 (0.76; 4.43) | 0.18 | 0.4 (0.18; 0.82) | 0.02 | 0.1 (0.04; 0.19) | < 0.001 |  |  | 0.79 (0.57; 1.09) | 0.15 | 0.57 (0.28; 1.17) | 0.13 |
 CelTOS | 1.55 (0.77; 3.13) | 0.22 | 0.41 (0.19; 0.85) | 0.02 | 0.1 (0.05; 0.2) | < 0.001 |  |  | 0.79 (0.57; 1.09) | 0.16 | 0.58 (0.28; 1.18) | 0.13 |
 RH4.9 | 0.62 (0.3; 1.26) | 0.19 | 0.53 (0.26; 1.05) | 0.07 | 0.08 (0.04; 0.16) | < 0.001 |  |  |  |  |  |  |
Group iii antigens | ||||||||||||
 DBL-α | 1.35 (0.62; 2.91) | 0.44 | 0.45 (0.21;0.92) | 0.03 | 0.12 (0.05; 0.24) | < 0.001 | 1.9 (0.88; 4.22) | 0.11 |  |  |  |  |
 RH5 | 1.93 (0.98; 4.01) | 0.07 | 0.38 (0.17; 0.79) | 0.01 | 0.11 (0.05; 0.21) | < 0.001 |  |  | 0.78 (0.56; 1.08) | 0.15 | 0.51 (0.24; 1.07) | 0.08 |
 SSP2 (TRAP) | 0.52 (0.26; 0.98) | 0.05 |  |  | 0.11 (0.05; 0.23) | < 0.001 | 2.29 (1.14; 4.8) | 0.02 |  |  |  |  |
 MSP1 Bl2 Mad20 | 0.61 (0.13; 2.7) | 0.52 | 0.55 (0.26; 1.13) | 0.11 | 0.14 (0.07; 0.3) | < 0.001 | 5.91 (1.5; 29.52) | 0.02 | 0.79 (0.57; 1.09) | 0.15 |  |  |
 MSP6 | 1.19 (0.56; 2.61) | 0.65 | 0.47 (0.21; 0.98) | 0.05 | 0.14 (0.06; 0.3) | < 0.001 | 1.63 (0.89; 3.01) | 0.12 | 0.78 (0.56; 1.07) | 0.12 | 0.51 (0.23; 1.09) | 0.08 |
 RH2 (2030) | 1.37 (0.72; 2.65) | 0.35 | 0.51 (0.25; 1.01) | 0.059 | 0.1 (0.04; 0.19) | < 0.001 |  |  |  |  | 0.55 (0.26; 1.16) | 0.12 |
 EBA175 R3–5 | 1.17 (0.71; 1.96) | 0.54 | 0.45 (0.21; 0.91) | 0.03 | 0.1 (0.05; 0.2) | < 0.001 |  |  | 0.79 (0.57; 1.09) | 0.16 | 0.55 (0.25; 1.18) | 0.13 |
 MSP5 | 0.78 (0.48; 1.25) | 0.3 | 0.49 (0.23; 1) | 0.056 | 0.12 (0.06; 0.24) | < 0.001 | 2.06 (1.26; 3.45) | 0.005 |  |  |  |  |
 EBA140 R3–5 | 1.21 (0.69; 2.14) | 0.5 | 0.47 (0.22; 0.94) | 0.04 | 0.09 (0.04; 0.18) | < 0.001 |  |  |  |  | 0.54 (0.24; 1.19) | 0.13 |
 MSP1 Bl2 RO33 | 0.53 (0.3; 0.93) | 0.03 | 0.53 (0.25; 1.07) | 0.08 | 0.1 (0.04; 0.21) | < 0.001 | 1.64 (0.93; 3.03) | 0.1 |  |  |  |  |
 MSP1 Bl2 Well | 0.55 (0.3; 0.99) | 0.05 | 0.51 (0.23; 1.07) | 0.08 | 0.1 (0.05; 0.2) | < 0.001 | 2.06 (0.95; 4.72) | 0.08 |  |  |  |  |
 MSP1 Bl2 3D7 | 0.63 (0.39; 1) | 0.054 | 0.47 (0.22; 0.96) | 0.042 | 0.08 (0.04; 0.17) | < 0.001 |  |  | 0.79 (0.56; 1.09) | 0.16 |  |  |
 RH4.2 | 0.85 (0.52; 1.38) | 0.51 | 0.53 (0.25; 1.06) | 0.08 | 0.09 (0.04; 0.18) | < 0.001 |  |  |  |  |  |  |