Table 3 Distribution of absolute and percentage change in haemoglobin and risk of anaemia by the treatment group and G6PD status

Day 2/3 (number of patients)

610*

471^†

338

334

258

137

 Absolute change^‡, mean (SD) [range]; g/dL

− 0.5 (1.1) [− 4.6 to 3.4]

− 1.1 (1.6) [− 6.4 to 5.0]

− 0.9 (1.2) [− 4.6 to 3.4]

− 1.2 (1.3) [−  4.2 to 5.0]

0.1 (0.6) [− 2.1 to 2.8]

− 1.0 (2.1) [− 6.4 to 3.8]

 Percentage change^‡, mean (SD) [range]; %

− 3.5 (8.5) [− 32.3 to 34.3]

− 8.0 (11.8) [− 39.4 to 60.8]

− 6.7 (9.0) [− 32.3 to 34.3]

− 8.8 (10.1) [− 39.4 to 60.8]

0.9 (5.4) [− 17.1 to 27.5]

− 6.2 (14.9) [− 35.8 to 35.5]

 Percentage fall > 25%

7/610 (1.1%)

27/471 (5.7%)

7/338 (2.1%)

11/334 (3.3%)

0/258 (0%)

16/137 (11.7%)

 > 25% fall associated with severe anaemia (%)^§

0/610 (0%)

1/471 (0.2%)

0/338 (0%)

1/334 (0.3%)

0/258 (0%)

0/137 (0%)

 Absolute fall > 5 g/dL^¶

0/610 (0%)

6/471 (1.3%)

0/338 (0%)

0/334 (0%)

0/258 (0%)

6/137 (4.4%)

Day 7 ± 2

1222

539

608

389

588

150

 Absolute change^‡, mean (SD) [range]; g/dL

− 0.1 (1.2) [− 5.6 to 6.5]

− 1.0 (1.6) [− 7.3 to 5.4]

− 0.2 (1.4) [− 4.6 to 6.5]

− 1.0 (1.5) [− 7.3 to 5.4]

0.1 (1.1) [− 5.6 to 5.4]

− 0.8 (2.0) [− 6.0 to 3.8]

 Percentage change^‡, mean (SD) [range]; %

0.4 (10.5) [− 40.6 to 64.4]

− 6.5 (12.3) [− 55.3 to 65.5]

− 0.7 (11.3) [− 33.0 to 64.4]

− 7.3 (11.5) [− 55.3 to 65.5]

1.7 (9.4) [− 40.6 to 52.4]

− 6.2 (14.9) [− 35.8 to 35.5]

 Percentage fall > 25%

5/1222 (0.4%)

33/539 (6.1%)

4/608 (0.7%)

20/389 (5.1%)

1/588 (0.2%)

13/150 (8.7%)

 > 25% fall associated with severe anaemia (%)^§

0/1220 (0%)

1/539 (0.2%)

0/608 (0%)

1/389 (0.3%)

0/586 (0%)

0/150 (0%)

Absolute fall > 5 g/dL^¶

1/1222 (0.1%)

8/539 (1.5%)

0/608 (0%)

4/389 (1.0%)

1/588 (0.2%)

4/150 (2.7%)

Day 28 ± 3

1579

917

731

472

826

444

 Absolute change^‡, mean (SD) [range]; g/dL

0.5 (1.4) [− 6.9 to 6.2]

0.4 (1.7) [− 6.8 to 6.7]

0.4 (1.5) [− 4.7 to 6.2]

0.4 (1.4) [− 4.2 to 6.2]

0.5 (1.4) [− 6.9 to 6.0]

0.5 (1.9) [− 6.8 to 6.7]

 Percentage change^‡, mean (SD) [range]; %

5.0 (13.4) [− 46.3 to 81.7]

5.1 (16.5) [− 51.1 to 136.7]

4.2 (13.1) [− 39.5 to 74.7]

4.2 (12.8) [− 36.2 to 74.8]

5.8 (13.7) [− 46.3 to 81.7]

6.1 (19.7) [− 51.1 to 136.7]

 Percentage fall > 25%

9/1579 (0.6%)

13/917 (1.4%)

6/731 (0.8%)

2/472 (0.4%)

3/826 (0.4%)

11/444 (2.5%)

 > 25% fall associated with severe anaemia (%)^§

1/1576 (0.1%)

3/906 (0.3%)

0/730 (0%)

0/472 (0%)

1/824 (0.1%)

3/433 (0.7%)

 Absolute fall > 5 g/dL^¶

1/1579 (0.1%)

3/917 (0.3%)

0/731 (0%)

0/472 (0%)

1/826 (0.1%)

3/444 (0.7%)