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Table 1 AGREE II scores

From: A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections

Guidelines Scope and purpose (%) Stakeholder involvement (%) Rigour of development (%) Clarity of presentation (%) Applicability (%) Editorial independence (%) Overall quality
Viral aetiology
 IEC 91.7 63.9 40.6 91.7 52.1 50.0 5
 EFNS 83.3 52.8 55.2 91.7 47.9 25.0 5
 DNS 38.7 27.7 22.1 41.8 16.6 0.0 3
 DGN: VM 69.4 44.4 50.0 75.0 20.8 66.7 5
 IDSA 72.2 50.0 58.3 86.1 18.8 83.3 6
 PHE: VE 88.9 75.0 44.8 86.1 31.3 50.0 6
 BIA: ABN 100 83.3 94.8 94.4 47.9 66.7 6
 BIA: ABN/BPAIIG 100 83.3 74.0 91.7 54.2 0.0 6
 AEPED 61.1 33.3 24.0 55.6 20.8 8.3 3
 SPILF 78 41.5 45.5 75.0 4.0 8.3 4
 Median 80.7 51.4 47.8 86.1 26.1 37.5 5.0
 Range (39–100) (22–83) (22–95) (42–94) (17–54) (0–83) (3–6)
Viral and bacterial aetiology
 NNF 75.0 52.8 37.5 88.9 6.3 29.2 4
 PHE: ME 97.2 69.4 28.1 94.4 43.8 83.3 5
 Median 86.1 61.1 32.8 91.7 25.1 56.3 4.5
 Range (75–97) (52–69) (28–38) (89–94) (6–44) (29–83) (4–5)
Bacterial aetiology
 EFNS 94.4 52.8 47.9 97.2 43.8 0.0 5
 ESCMID 100 83.3 88.5 88.9 47.9 66.7 7
 DSI 75.0 36.1 20.8 86.1 45.8 0.0 4
 SPILF 83.3 38.9 44.8 88.9 25.0 0.0 4
 DGN: BM 69.4 44.4 50.0 75.0 20.8 66.7 5
 HPSC 100 66.7 45.8 94.4 39.6 0.0 5
 NVN 97.2 94.4 87.6 97.2 66.7 29.2 7
 MHSSE 100 94.4 90.6 86.1 43.8 50.0 7
 NICE 100 86.1 95.8 88.9 79.2 70.8 7
 UKJSS 100 88.9 77.1 94.4 47.9 50.0 7
 SIGN 91.7 91.7 79.2 86.1 37.5 45.8 7
 IDSA 75.0 50.0 59.4 86.1 10.4 54.2 5
 AEPED 61.1 33.3 19.8 83.3 20.8 0.0 3
 MSF 88.9 47.2 9.4 91.7 50.0 0.0 4
 Median 93.1 59.8 54.7 88.9 43.8 37.5 5
 Range (61–100) (33–94) (9–96) (75–97) (10–79) (0–71) (3–7)
  1. Abbreviations: IEC International Encephalitis Consortium, EFNS European Federation of Neurological Societies, DNS Dansk Neurologisk Selskab, DGN: VM Deutsche Gesellschaft für Neurologie: Virale Meningoeczephalitis, PHE: VE Public Health England: Viral Encephalitis, BIA: ABN British Infection Association: Association of British Neurologists, BPAIIG The British Paediatric Allergy Immunology and Infections Group, AEPED Asociación Española de Pediatría, SPILF Société de Pathologie Infectieuse de Langue Française, PHE: ME Public Health England: Meningoencephalitis, NNF Norsk Nevrologisk Forening, ESCMID European Society of Clinical Microbiology and Infectious Diseases, DSI Dansk Selskab for Infektionsmedicin, DGN: BM Deutsche Gesellschaft für Neurologie: Bakterielle Meningoenzephalitis, HPSC Health Protection Surveillance Centre, NVN Nederlandse Vereniging voor Neurologie, MHSSE Ministry of Health, Social Services and quality, NICE The National Institute for Health and Care Excellence, UKJSS UK Joint Specialist Societies, SIGN Scottish Intercollegiate Guidelines Network, IDSA Infectious Diseases Society of America, MSF Médecins Sans Frontières