Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes

Table 4 GWAS results for age at onset and for C-peptide adjusted for sex, age at onset and duration: associations with SNPs previously reported

Chr	SNP	Position	Alleles	Freq	Score age onset	p value age onset	Score C-peptide	p value C-peptide
1	rs2476601	114377568	A/G	0.83	9.4	0.7	160.8	3e −04
6	rs72975913	128293932	A/C	0.85	−36.9	0.1	−16.9	0.7
10	rs1983890	6178614	T/C	0.66	−28.9	0.4	−32.4	0.6
6	rs9260151	29911030	T/C	0.91	−39.1	0.04	−100.6	0.003
6	rs1264813	29939900	T/C	0.91	96.6	3e −07	123.3	2e −04
6	rs61211515	30100975	C/CT	0.87	79.2	3e −04	107.3	0.005
6	rs3135002	32668439	A/C	0.96	−124.2	6e −20	−258.3	3e −28
1	rs559047	238753916	A/T	0.77	−16.9	0.6	−37	0.5

Sources for reported association: rs2476601 (C1858T variant in PTPN22) [22], rs72975913 [23], rs1983890 [24], all others [6]

ISSN: 1741-7015