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Fig. 3 | BMC Medicine

Fig. 3

From: Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

Fig. 3

Instrumental variable estimates for mortality. Analyses of two-SNP score with mortality were estimated using cox proportional hazard regression models. We used a two-SNP score as instrument to estimate the influence of a 25 nmol/L increase in 25(OH)D concentrations on risk of mortality. We calculated instrumental variable estimates of genetically determined hazard ratios by using the Wald-type estimator, which involves taking the ratio of the gene-outcome log hazard ratios to the gene-exposure coefficient and then exponentiating to express it as a hazard ratio. Number of individuals in CKB and CGPS are 99,012 and 106,911, respectively. Two-SNP score was calculated based on DHCR7 + CYP2R1: rs12785878 + rs10741657 in CKB and DHCR7 + CYP2R1: rs7944926 + rs10741657 in CGPS. The r2 between rs12785878 and rs7944926 is 0.87. All values are adjusted for age, sex, and season and stratified by region

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BMC Medicine

ISSN: 1741-7015

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