Table 4 Observational association of 25(OH)D with lipids in CKB, CGPS, and CCHS
Lipids | Continuous 25(OH)D per 25 nmol/L | 25(OH)D quartiles (nmol/L) | P for trend | |||
|---|---|---|---|---|---|---|
Beta ± SE | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |||
CKB (n = 17,755) | ||||||
Apoa, mg/dL | 1.52 ± 0.21 | 127.90 ± 0.43 | 129.48 ± 0.42 | 129.79 ± 0.41 | 130.73 ± 0.45 | < 0.0001 |
Apob, mg/dL | 0.04 ± 0.00 | 84.52 ± 0.46 | 85.95 ± 0.45 | 84.14 ± 0.44 | 81.42 ± 0.44 | < 0.0001 |
Lpa, mmol/L | 0.01 ± 0.49 | 37.94 ± 1.00 | 36.40 ± 0.99 | 35.17 ± 0.96 | 37.15 ± 1.02 | 0.984 |
TC, mmol/L | −0.05 ± 0.01 | 4.65 ± 0.02 | 4.74 ± 0.02 | 4.66 ± 0.02 | 4.53 ± 0.02 | < 0.0001 |
HDL, mmol/L | 0.03 ± 0.01 | 1.20 ± 0.01 | 1.22 ± 0.01 | 1.23 ± 0.01 | 1.26 ± 0.01 | < 0.0001 |
LDL, mmol/L | −0.03 ± 0.01 | 2.32 ± 0.01 | 2.38 ± 0.01 | 2.34 ± 0.01 | 2.28 ± 0.02 | < 0.0001 |
TG, mmol/L | −0.16 ± 0.02 | 2.18 ± 0.04 | 2.09 ± 0.03 | 2.03 ± 0.03 | 1.75 ± 0.03 | < 0.0001 |
CGPS and CCHS (n = 106,911) | ||||||
Apoa, mg/dL* | 0.01 ± 0.002 | 160.63 ± 31.08 | 161.78 ± 29.96 | 163.35 ± 30.09 | 164.39 ± 32.33 | < 0.0001 |
Apob, mg/dL* | −0.08 ± 0.002 | 125.27 ± 40.06 | 118.58 ± 35.59 | 112.93 ± 33.17 | 104.34 ± 29.31 | < 0.0001 |
Lpa, mg/dL* | 0.32 ± 0.231 | 22.99 ± 31.53 | 22.80 ± 30.25 | 22.83 ± 32.66 | 23.90 ± 31.30 | 0.15 |
TC, mmol/L | −0.14 ± 0.006 | 5.85 ± 1.16 | 5.80 ± 1.12 | 5.71 ± 1.10 | 5.53 ± 1.09 | < 0.0001 |
HDL, mmol/L | 0.06 ± 0.003 | 1.38 ± 0.50 | 1.46 ± 0.51 | 1.51 ± 0.51 | 1.56 ± 0.52 | < 0.0001 |
LDL, mmol/L* | −0.15 ± 0.006 | 3.44 ± 1.00 | 3.36 ± 0.96 | 3.27 ± 0.95 | 3.09 ± 0.91 | < 0.0001 |
TG, mmol/L* | −0.26 ± 0.007 | 2.08 ± 1.49 | 1.78 ± 1.10 | 1.60 ± 0.95 | 1.39 ± 0.77 | < 0.0001 |