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Table 4 Observational association of 25(OH)D with lipids in CKB, CGPS, and CCHS

From: Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

Lipids Continuous 25(OH)D per 25 nmol/L 25(OH)D quartiles (nmol/L) P for trend
Beta ± SE Quartile 1 Quartile 2 Quartile 3 Quartile 4
Mean ± SD Mean ± SD Mean ± SD Mean ± SD
CKB (n = 17,755)
 Apoa, mg/dL 1.52 ± 0.21 127.90 ± 0.43 129.48 ± 0.42 129.79 ± 0.41 130.73 ± 0.45 < 0.0001
 Apob, mg/dL 0.04 ± 0.00 84.52 ± 0.46 85.95 ± 0.45 84.14 ± 0.44 81.42 ± 0.44 < 0.0001
 Lpa, mmol/L 0.01 ± 0.49 37.94 ± 1.00 36.40 ± 0.99 35.17 ± 0.96 37.15 ± 1.02 0.984
 TC, mmol/L −0.05 ± 0.01 4.65 ± 0.02 4.74 ± 0.02 4.66 ± 0.02 4.53 ± 0.02 < 0.0001
 HDL, mmol/L 0.03 ± 0.01 1.20 ± 0.01 1.22 ± 0.01 1.23 ± 0.01 1.26 ± 0.01 < 0.0001
 LDL, mmol/L −0.03 ± 0.01 2.32 ± 0.01 2.38 ± 0.01 2.34 ± 0.01 2.28 ± 0.02 < 0.0001
 TG, mmol/L −0.16 ± 0.02 2.18 ± 0.04 2.09 ± 0.03 2.03 ± 0.03 1.75 ± 0.03 < 0.0001
CGPS and CCHS (n = 106,911)
 Apoa, mg/dL* 0.01 ± 0.002 160.63 ± 31.08 161.78 ± 29.96 163.35 ± 30.09 164.39 ± 32.33 < 0.0001
 Apob, mg/dL* −0.08 ± 0.002 125.27 ± 40.06 118.58 ± 35.59 112.93 ± 33.17 104.34 ± 29.31 < 0.0001
 Lpa, mg/dL* 0.32 ± 0.231 22.99 ± 31.53 22.80 ± 30.25 22.83 ± 32.66 23.90 ± 31.30 0.15
 TC, mmol/L −0.14 ± 0.006 5.85 ± 1.16 5.80 ± 1.12 5.71 ± 1.10 5.53 ± 1.09 < 0.0001
 HDL, mmol/L 0.06 ± 0.003 1.38 ± 0.50 1.46 ± 0.51 1.51 ± 0.51 1.56 ± 0.52 < 0.0001
 LDL, mmol/L* −0.15 ± 0.006 3.44 ± 1.00 3.36 ± 0.96 3.27 ± 0.95 3.09 ± 0.91 < 0.0001
 TG, mmol/L* −0.26 ± 0.007 2.08 ± 1.49 1.78 ± 1.10 1.60 ± 0.95 1.39 ± 0.77 < 0.0001
  1. Linear regression was also used to assess the associations of 25(OH)D with lipids
  2. All values are adjusted for age (years), sex (male or female), smoking status (current smoker), alcohol intake (current drinker), season, SBP, and physical activity (low activity) in CKB
  3. All values are adjusted for age (years), sex (male or female), latitude, season, region, SBP, physical activity (METs, h/day), smoking status (never smoker, occasional smoker, former smoker, or regular smoker), and alcohol intake (non-drinker, occasional drinker, former drinker, or regular drinker) in CGPS and CCHS
  4. *Data only available in CGPS