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Table 4 Summary of the results for the top 3 variants from the association testing

From: Dissecting genetic factors affecting phenylephrine infusion rates during anesthesia: a genome-wide association study employing EHR data

SNP

Average infusion rate

Resistant vs. sensitive

Resistant vs. (sensitive + intermediate)

Phase I (N = 1205)

Phase II (N = 329)

Phase I (N = 589)

Phase II (N = 147)

Phase I (N = 1205)

Phase II (N = 329)

β

P

β

P

OR

P

OR

P

OR

P

OR

P

rs2069661 (F2RL2)

13.71 (7.81~19.6)

5.71E−06

14.32 (3.28~25.4)

0.012

3.50 (1.52~8.05)

3.19E−03

1.84 (0.26~13.18)

0.545

3.90 (1.97~7.70)

9.12E−05

2.28 (0.43~12.22)

0.335

 Sex

− 4.05 (− 6.34~− 1.76)

5.44E−04

1.44 (− 2.87~5.74)

0.513

0.50 (0.33~0.75)

7.97E−04

0.59 (0.25~1.35)

0.210

0.71 (0.50~1.03)

0.068

1.00 (0.48~2.08)

0.995

 Age

0.08 (− 0.01~0.17)

0.078

0.16 (− 0.01~0.32)

0.065

0.97 (0.96~0.99)

2.58E−03

0.99 (0.95~1.02)

0.429

1.01 (0.99~1.02)

0.335

1.00 (0.97~1.03)

0.974

 Body weight

0.14 (0.09~0.19)

6.84E−08

0.18 (0.09~0.27)

1.19E−04

1.01 (1.00~1.02)

0.019

1.02 (0.99~1.04)

0.139

1.01 (1.01~1.02)

4.40E−04

1.01 (0.997~1.03)

0.112

 SNPxWeight

0.33 (0.08~0.57)

9.26E−03

0.05 (− 0.75~0.85)

0.895

1.01 (0.98~1.05)

0.512

1.04 (0.90~1.21)

0.581

1.02 (0.99~1.06)

0.172

1.02 (0.91~1.15)

0.695

rs77080086 (PDE4B)

12.17 (7.43~16.91)

5.50E−07

6.43 (− 3.32~16.2)

0.197

1.40 (0.69~2.8)

0.35

1.59 (0.33~7.57)

0.562

1.75 (0.93~3.30)

0.082

1.7 (0.40~7.21)

0.468

 Sex

− 3.81 (− 6.09~− 1.53)

1.08E−03

1.10 (− 3.24~5.45)

0.620

0.51 (0.34~0.77)

1.09E−03

0.55 (0.24~1.26)

0.155

0.74 (0.51~1.06)

0.098

0.95 (0.46~1.97)

0.899

 Age

0.07 (− 0.02~0.02)

0.115

0.16 (− 0.01~0.33)

0.060

0.97 (0.96~0.99)

2.20E−03

0.99 (0.95~1.02)

0.459

1.01 (0.99~1.02)

0.387

1.00 (0.97~1.03)

0.943

 Body weight

0.14 (0.09~0.19)

5.69E−08

0.18 (0.09~0.27)

8.74E−05

1.01 (1.00~1.02)

0.016

1.02 (0.996~1.04)

0.125

1.01 (1.01~1.02)

4.42E−04

1.01 (0.998~1.03)

0.096

 SNPxWeight

− 0.05 (− 0.26~0.17)

0.679

0.36 (− 0.40~1.11)

0.354

0.99 (0.96~1.02)

0.641

0.99 (0.90~1.09)

0.832

1.00 (0.98~1.03)

0.953

1.00 (0.91~1.11)

0.995

rs11572377 (EDN2)

12.26 (6.32~18.2)

5.44E−05

15.14 (5.08~25.19)

3.41E−03

3.95 (1.30~11.97)

0.015

5.97 (1.35~26.32)

0.018

2.03 (0.97~4.25)

0.047

4.3 (1.28~14.63)

0.018

 Sex

− 4.05 (− 6.32~− 1.78)

4.86E−04

0.88 (− 3.40~5.17)

0.687

0.52 (0.35~0.78)

1.72E−03

0.54 (0.23~1.26)

0.151

0.72 (0.50~1.04)

0.079

0.9 (0.45~1.94)

0.848

 Age

0.078 (− 0.01~0.17)

0.086

0.17 (0.01~0.03)

0.038

0.97 (0.96~0.99)

4.42E−03

1.00 (0.96~1.02)

0.526

1.01 (0.99~1.02)

0.335

1.0 (0.97~1.03)

0.862

 Body weight

0.13 (0.08~0.18)

3.28E−07

0.18 (0.09~0.27)

1.32E−04

1.01 (1.00~1.02)

0.021

1.02 (0.998~1.04)

0.068

1.01 (1.01~1.02)

7.83E−04

1.0 (0.997~1.03)

0.110

 SNPxWeight

0.01 (− 0.22~0.24)

0.96

− 0.26 (− 0.61~0.10)

0.155

1.05 (0.97~1.12)

0.219

0.97 (0.88~1.06)

0.479

1.01 (0.98~1.03)

0.613

0.96 (0.91~1.01)

0.120

  1. The effect sizes for SNP, sex, age, and body weight were the main effect size in linear or logistic regression models for the quantitative or categorical traits respectively. The effect size of SNP × Weight was the effects of the interaction terms in the models which include only the SNP, body weight, and their interaction. Regression β and odds ratio (OR) were presented as mean (95% confidence interval)
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BMC Medicine

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