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Fig. 1 | BMC Medicine

Fig. 1

From: Representation of people with comorbidity and multimorbidity in clinical trials of novel drug therapies: an individual-level participant data analysis

Fig. 1

a Initial identification of individual-level participant data trials from trial repositories. See Additional file 1 for a detailed description of the selection process. Abbreviations are as follows: MeSH, Medical Subject Headings; WHO-ATC, World Health Organization Anatomic Therapeutic Chemical classification scheme; CSDR, Clinical Study Data Request repository; YODA, Yale Open Data Access repository; NIH, National Institutes of Health Biologic Specimen and Data Repository Information Coordinating Center repository; and IPD, individual-level participant data. b Definition of “denominator trials” using the US clinical trials registry (clinicaltrials.gov) and the effect of restricting the individual-level participant data trials to this denominator set. The height of each box on the horizontal axis corresponds to the simultaneous effect of applying the eligibility criteria to the denominator set of trials (the leftmost chart) and the three numerator sets of IPD trials. For brevity, the leftmost flowchart shows both the eligibility criteria and the trial counts whereas the other three flowcharts show only the trial counts. Of the final set of 124 trials, further 8 trials were excluded either because the index condition was either difficult or impossible to accurately identify within the primary care record or because we judged that concomitant medication may be difficult to interpret in the context of the index condition (see Additional file 1, section 1.7 for details)

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