Table 3 Risk estimates: absolute risk reduction (ARR) or increase (ARI) and number needed to treat (NNT) or to harm (NNH) for the primary and secondary endpoints over a treatment period of 1Â year, which were statistically different between groups
Event | Events per 100 patient years in the aspirin group | Events per 100 patient years in the control group | ARR % | ARI % | NNT | NNH | Events prevented per 10,000 treated patients | Events caused per 10,000 treated patients | p value |
|---|---|---|---|---|---|---|---|---|---|
Myocardial infarction | 0.260 | 0.301 | 0.041 | Â | 2452 | Â | 4 | Â | 0.005 |
Ischemic stroke | 0.218 | 0.240 | 0.022 | Â | 4448 | Â | 2 | Â | 0.03 |
MACE | 0.613 | 0.665 | 0.052 |  | 1908 |  | 5 |  | < 0.0001 |
Major bleeding | 0.257 | 0.180 |  | 0.077 |  | 1295 |  | 8 | < 0.0000 |
Extracranial major bleeding | 0.286 | 0.218 |  | 0.068 |  | 1462 |  | 7 | < 0.0000 |
GI bleeding | 0.399 | 0.320 |  | 0.079 |  | 1263 |  | 8 | < 0.0001 |