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Table 1 General characteristics of FASSTT Offspring Trial participants at age 3 and 7 years

From: Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)

  Participants at 3 years (n = 39) Participants at 7 years (n = 70)
Placebo (n = 16) Folic acid (n = 23) Placebo (n = 33) Folic acid (n = 37)
Maternal characteristics
 Age, yearsa 27.1 (25.1, 29.0) 28.8 (27.2, 30.4) 28.0 (26.4, 29.6) 29.4 (28.2, 30.7)
 BMI, kg/m2 25.0 (22.9, 27.1) 25.7 (22.8, 28.6) 24.3 (23.1, 25.6) 25.3 (23.5, 27.2)
 Smoking in pregnancy, % 38 22 12 19
 Alcohol use, % 6 0 3 3
 Duration of folic acid use at time of enrolment, weeks 13.5 (8.4, 18.6) 12.0 (9.0, 15.0) 13.6 (10.7, 16.4) 12.8 (10.5, 15.1)
 Iron supplement use, % 25 22 18 27
 Married, % 73 91 88 95
 Education attainment, yearsb 19.2 (17.8, 20.6) 19.7 (18.5, 20.9) 19.6 (18.5, 20.6) 19.5 (18.5, 20.4)
 Homeowner, % 60 76 79 76
 Parity (n) 2.9 (2.5, 3.3) 3.2 (2.7, 3.6) 2.6 (2.3, 2.9) 2.8 (2.5, 3.1)
 Week of gestation at labor 40.0 (39.3, 40.7) 40.0 (39.3, 40.6) 40.2 (40.0, 40.7) 39.9 (3.94, 40.3)
Child characteristics at birth
 Sex, female % 75 65 48 59
 Birth weight, g 3392 (3144, 3640) 3317 (3029, 3605) 3519 (3323, 3716) 3374 (3188, 3559)
 Birth length, cm 51.1 (49.9, 52.4) 50.6 (49.6, 51.7) 51.4 (50.4, 52.4) 50.8 (50.1, 51.5)
 Head circumference, cm 34.4 (33.6, 35.2) 34.4 (33.6, 35.2) 34.6 (34.1, 35.2) 34.6 (34.1, 35.1)
 Apgar at 1st minute 8.3 (7.6, 8.9) 8.5 (8.2, 8.8) 8.5 (8.1, 8.9) 8.7 (8.5, 8.8)
 Apgar at 5th minute 9.0 (9.0, 9.0) 9.0 (8.9, 9.1) 9.0 (8.8, 9.1) 9.0 (8.9, 9.1)
 Breastfed from birth, % 56 44 39 46
Child characteristics at follow-up
 Age at assessment, years 2.8 (2.5, 3.0) 2.7 (2.6, 2.9) 6.8 (6.7, 6.9) 6.7 (6.7, 6.8)
 BMI Z-scorec 0.55 (− 0.39, 1.48) 0.19 (− 0.19, 0.57) 0.24 (− 0.11, 0.58) − 0.08 (− 0.40, 0.23)
  1. Continuous measures presented as mean (95% CI), unless otherwise indicated. Categorical measures compared using Pearson’s chi-square, as appropriate
  2. aAge of mother at enrolment to the FASSTT trial
  3. bAge of leaving of formal education
  4. cBody mass index (BMI) was calculated as weight in kilograms/height in meters squared. BMI Z-score was calculated based on the Centre for Disease Control Growth Charts and using the LMS method, using the equation Z = (BMI/M)^L − 1)/(L × S) [23]. The parameters of the formula include the following: M which is the median BMI by age, S which corresponds to the coefficient of variation of BMI, and L which allows for age-dependent skewness in the distribution of body mass index [24]
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