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Table 3 WPPSI-III test scores of FASSTT Offspring Trial participants at 7 years

From: Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)

Composite and subtest scores Placebo (n = 33) Folic acid (n = 37) Difference p value (unadjusted)a p value (adjusted)b
Verbal IQ 103.4 (99.4, 107.4) 107.7 (103.7, 111.8) 4.3 (− 1.2, 9.9) 0.126 0.120
Information 10.9 (9.9, 11.8) 11.1 (10.3, 12.0) 0.3 (− 1.0, 1.5) 0.648 0.630
Vocabulary 9.6 (8.9, 10.4) 10.3 (9.5, 11.1) 0.7 (− 0.4, 1.8) 0.221 0.262
Word reasoning 11.9 (11.0, 12.8) 13.3 (12.4, 14.2) 1.4 (0.2, 2.6) 0.023 0.027
Performance IQ 100.6 (96.5, 104.6) 104.1 (99.1, 109.1) 3.5 (− 2.9, 9.8) 0.274 0.429
Processing speed 103.9 (98.1, 109.7) 102.5 (97.4, 107.7) 1.4 (− 6.2, 8.9) 0.718 0.712
General language 105.8 (101.1, 110.5) 108.9 (104.5, 113.2) 3.1 (− 3.2, 9.4) 0.334 0.514
Full scale IQ 103.5 (99.3, 107.6) 106.4 (101.7, 111.1) 3.0 (− 3.3, 9.2) 0.348 0.441
  1. Data presented as mean (95% CI)
  2. Test scores assessed by Wechsler Preschool and Primary Scale of Intelligence test, 3rd UK edition (WPPSI-III)
  3. Data analyzed by aindependent t test and bANCOVA, with adjustment for maternal age and education attainment [28], child’s sex [29, 30], birth weight [31], and breastfeeding [28]. Results considered significant when p < 0.05
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