Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)

Table 5 Developmental scores of FASSTT Offspring Trial participants at 3 years

Developmental domains	Placebo (n = 16)	Folic acid (n = 23)	Difference	p value (unadjusted)^a	p value (adjusted)^b
Cognitive^a	9.5 (8.8, 10.2)	10.3 (9.3, 11.3)	0.8 (− 0.5, 2.1)	0.223	0.040
Receptive communication	10.3 (9.0, 11.5)	10.5 (9.4, 11.6)	0.2 (− 1.4, 1.8)	0.775	0.395
Expressive communication	11.3 (10.0, 12.5)	10.3 (9.1, 11.5)	1.0 (− 0.7, 2.7)	0.257	0.634
Fine motor	9.8 (8.9, 10.7)	10.4 (9.1, 11.6)	0.5 (− 1.1, 2.2)	0.515	0.302
Gross motor	8.6 (7.5, 9.6)	8.6 (7.7, 9.4)	0.0 (− 1.3, 1.3)	0.997	0.828

Data presented as mean (95% CI)
Developmental scores assessed by the BSITD-III
Data analyzed by ^aindependent t test and ^bANCOVA, adjusting for maternal age and education attainment [28], and child’s birth weight [31]. Results considered significant when p < 0.05

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