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Table 5 Developmental scores of FASSTT Offspring Trial participants at 3 years

From: Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)

Developmental domains Placebo (n = 16) Folic acid (n = 23) Difference p value (unadjusted)a p value (adjusted)b
Cognitivea 9.5 (8.8, 10.2) 10.3 (9.3, 11.3) 0.8 (− 0.5, 2.1) 0.223 0.040
Receptive communication 10.3 (9.0, 11.5) 10.5 (9.4, 11.6) 0.2 (− 1.4, 1.8) 0.775 0.395
Expressive communication 11.3 (10.0, 12.5) 10.3 (9.1, 11.5) 1.0 (− 0.7, 2.7) 0.257 0.634
Fine motor 9.8 (8.9, 10.7) 10.4 (9.1, 11.6) 0.5 (− 1.1, 2.2) 0.515 0.302
Gross motor 8.6 (7.5, 9.6) 8.6 (7.7, 9.4) 0.0 (− 1.3, 1.3) 0.997 0.828
  1. Data presented as mean (95% CI)
  2. Developmental scores assessed by the BSITD-III
  3. Data analyzed by aindependent t test and bANCOVA, adjusting for maternal age and education attainment [28], and child’s birth weight [31]. Results considered significant when p < 0.05