Fig. 3

Time trends of fatal, hospitalised and primary care bleeding events and antithrombotic prescribing 1998–2010 in CALIBER. a Fatal, hospitalised+MS and primary care+MS bleeding events. b Hospitalised and primary care bleeding events. c Prescriptions for ADP receptor inhibitors, aspirin and vitamin K antagonists. Fitted lines are Loess smoothed curves with shaded 95% confidence intervals. MS, markers of severity; ATT, antithrombotic therapy; VKA, vitamin K antagonists