Fig. 1
From: NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis
Ablation of NG2 glia exacerbates neuroinflammation in response to LPS. a Schematic representation of the administration paradigm used for NG2 glia ablation in iDTR adult mouse brain using diphtheria toxin (DT) administration (i.p.). DT (300 ng/day) was given twice a day for 3.5 days. b Representative graph showing relative mRNA levels of inflammatory mediators in the indicated brain regions from DTRNG2 and control mice. c The expression of IL-1β in the striatum of DTRNG2 Tg mouse brain. Immunoblot analyses of tissue lysates from DTRNG2 Tg mice and their counterparts 4 h after LPS challenge. d Quantification of data shown in c. Error bars represent mean ± SEM; (n = 2–5). Two-way ANOVA with Bonferroni’s post test was used. *P<0.05, **P < 0.01, ***P < 0.001