Fig. 4

Metabolic trajectories compared between insulin-resistant individuals in the normal glucose tolerance group (blue) and those with 2-h impaired glucose tolerance (red). IR-NGT, indiviudals with normal glucose tolerance and in the top quartile of fasting insulin (n = 713); IGT/NDM, Individuals with 2-h impaired glucose tolerance, including those with impaired glucsoe tolerance and new onset of type 2 diabetes (n = 518). The dots and error bars denote mean percentage changes and 95% confidence intervals, respectively. The asterisk denotes that there are signficiant differences between IR-NGT and those with IGT or NDM at corresponding time point. a Insulin and glucose. b Glycolysis-related. c Branched-chain amino acids. d Ketone bodies. e Triglycerides-related