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Table 1 Characteristics of the Northern Finland Birth Cohort 1966

From: Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study

 Without glucose abnormalityWith glucose abnormality
All NGTIS-NGTIR-NGTIFGIGTNDM
N28477087131380412106
Age [year]46.7 [46.2–47.1]46.5 [46.2–46.9]46.8 [46.4–47.3]46.6 [46.2–47.1]46.7 [46.3–47.2]46.8 [46.3–47.2]
Men [%]343338614863
BMI [kg/m2]24.9 [22.7–27.6]23.1 [21.6–25.1]27.8 [25.1–30.9]27.0 [24.6–29.9]29.2 [26.3–32.4]30.0 [27.3–33.3]
Systolic blood pressure [mmHg]120 [111–131]118 [109–128]125 [114–135]128 [118–138]130 [122–142]136 [124–150]
Diastolic blood pressure [mmHg]82 [75–89]79 [73–86]85 [78–93]86 [80–93]90 [82–97]94 [86–100]
Triglycerides [mmol/L]1.0 [0.7–1.3]0.8 [0.6–1.1]1.3 [1.0–1.7]1.3 [0.9–1.8]1.6 [1.1–2.2]1.7 [1.3–2.2]
LDL cholesterol [mmol/L]1.8 [1.5–2.2]1.7 [1.5–2.2]1.9 [1.6–2.4]2.0 [1.6–2.4]1.9 [1.6–2.3]2.0 [1.7–2.3]
HDL cholesterol [mmol/L]1.7 [1.4–1.9]1.8 [1.6–2.0]1.5 [1.3–1.7]1.5 [1.3–1.8]1.4 [1.2–1.7]1.4 [1.1–1.6]
Fasting insulin [mU/L]6.5 [4.6–9.5]3.6 [3.0–4.1]12.2 [10.6–14.9]9.8 [6.9–13.5]12.4 [8.3–18.3]15.5 [10.5–24.4]
2 h insulin [mU/L]37.0 [25.2–53.2]25.2 [17.9–34.2]59.9 [41.9–92.8]47.9 [31.6–77.6]120.4 [68.8–187.4]129.9 [66.0–195.5]
Fasting glucose [mmol/L]5.2 [5.0–5.4]5.0 [4.8–5.3]5.3 [5.1–5.4]5.8 [5.7–6.0]5.7 [5.4–6.1]6.9 [6.3–7.2]
2 h glucose [mmol/L]5.2 [4.6–5.9]4.9 [4.3–5.6]5.6 [4.9–6.3]5.9 [5.1–6.6]8.6 [8.1–9.2]11.5 [8.4–12.6]
HOMA-IR1.5 [1.0–2.2]0.8 [0.7–0.9]2.8 [2.5–3.5]2.5 [1.8–3.5]3.2 [2.0–4.7]4.5 [3.2–7.6]
ISI (Matsuda)6.3 [4.4–8.6]10.6 [8.9–12.7]3.4 [2.6–4.2]3.8 [2.6–5.5]2.5 [1.7–3.9]1.9 [1.2–3.0]
Insulinogenic index21.7 [13.3–38.2]15.7 [9.9–26.2]32.2 [20.2–49.2]20.7 [12.6–33.2]18.0 [10.5–30.2]10.8 [7.6–20.2]
  1. Values are median [interquartile range]. Characteristics for the replication cohort Oulu45 is shown in Additional file 1: Table S1
  2. Abbreviations: BMI body mass index, NGT normal glucose tolerance, IFG isolated impaired fasting glucose, IGT isolated impaired glucose tolerance, NDM new type 2 diabetes, IS-NGT insulin-sensitive individuals within NGT (at the first quartile of fasting insulin within NGT), IR-NGT insulin-resistant individuals within NGT (at the top quartile of fasting insulin within NGT)
  3. HOMA-IR = fasting glucose (mmol/L) × fasting insulin (mIU/L)/22.5
  4. ISI-Matsuda = 10,000/square root of [fasting glucose (mg/dL) × fasting insulin (mIU/L) × mean glucose × mean insulin during OGTT]
  5. Insulinogenic index = (Insulin30 (mIU/L) − Insulin0)/(Glucose30(mmol/L) − Glucose0) during OGTT