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Table 1 Characteristics of the Northern Finland Birth Cohort 1966

From: Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study

 

Without glucose abnormality

With glucose abnormality

All NGT

IS-NGT

IR-NGT

IFG

IGT

NDM

N

2847

708

713

1380

412

106

Age [year]

46.7 [46.2–47.1]

46.5 [46.2–46.9]

46.8 [46.4–47.3]

46.6 [46.2–47.1]

46.7 [46.3–47.2]

46.8 [46.3–47.2]

Men [%]

34

33

38

61

48

63

BMI [kg/m2]

24.9 [22.7–27.6]

23.1 [21.6–25.1]

27.8 [25.1–30.9]

27.0 [24.6–29.9]

29.2 [26.3–32.4]

30.0 [27.3–33.3]

Systolic blood pressure [mmHg]

120 [111–131]

118 [109–128]

125 [114–135]

128 [118–138]

130 [122–142]

136 [124–150]

Diastolic blood pressure [mmHg]

82 [75–89]

79 [73–86]

85 [78–93]

86 [80–93]

90 [82–97]

94 [86–100]

Triglycerides [mmol/L]

1.0 [0.7–1.3]

0.8 [0.6–1.1]

1.3 [1.0–1.7]

1.3 [0.9–1.8]

1.6 [1.1–2.2]

1.7 [1.3–2.2]

LDL cholesterol [mmol/L]

1.8 [1.5–2.2]

1.7 [1.5–2.2]

1.9 [1.6–2.4]

2.0 [1.6–2.4]

1.9 [1.6–2.3]

2.0 [1.7–2.3]

HDL cholesterol [mmol/L]

1.7 [1.4–1.9]

1.8 [1.6–2.0]

1.5 [1.3–1.7]

1.5 [1.3–1.8]

1.4 [1.2–1.7]

1.4 [1.1–1.6]

Fasting insulin [mU/L]

6.5 [4.6–9.5]

3.6 [3.0–4.1]

12.2 [10.6–14.9]

9.8 [6.9–13.5]

12.4 [8.3–18.3]

15.5 [10.5–24.4]

2 h insulin [mU/L]

37.0 [25.2–53.2]

25.2 [17.9–34.2]

59.9 [41.9–92.8]

47.9 [31.6–77.6]

120.4 [68.8–187.4]

129.9 [66.0–195.5]

Fasting glucose [mmol/L]

5.2 [5.0–5.4]

5.0 [4.8–5.3]

5.3 [5.1–5.4]

5.8 [5.7–6.0]

5.7 [5.4–6.1]

6.9 [6.3–7.2]

2 h glucose [mmol/L]

5.2 [4.6–5.9]

4.9 [4.3–5.6]

5.6 [4.9–6.3]

5.9 [5.1–6.6]

8.6 [8.1–9.2]

11.5 [8.4–12.6]

HOMA-IR

1.5 [1.0–2.2]

0.8 [0.7–0.9]

2.8 [2.5–3.5]

2.5 [1.8–3.5]

3.2 [2.0–4.7]

4.5 [3.2–7.6]

ISI (Matsuda)

6.3 [4.4–8.6]

10.6 [8.9–12.7]

3.4 [2.6–4.2]

3.8 [2.6–5.5]

2.5 [1.7–3.9]

1.9 [1.2–3.0]

Insulinogenic index

21.7 [13.3–38.2]

15.7 [9.9–26.2]

32.2 [20.2–49.2]

20.7 [12.6–33.2]

18.0 [10.5–30.2]

10.8 [7.6–20.2]

  1. Values are median [interquartile range]. Characteristics for the replication cohort Oulu45 is shown in Additional file 1: Table S1
  2. Abbreviations: BMI body mass index, NGT normal glucose tolerance, IFG isolated impaired fasting glucose, IGT isolated impaired glucose tolerance, NDM new type 2 diabetes, IS-NGT insulin-sensitive individuals within NGT (at the first quartile of fasting insulin within NGT), IR-NGT insulin-resistant individuals within NGT (at the top quartile of fasting insulin within NGT)
  3. HOMA-IR = fasting glucose (mmol/L) × fasting insulin (mIU/L)/22.5
  4. ISI-Matsuda = 10,000/square root of [fasting glucose (mg/dL) × fasting insulin (mIU/L) × mean glucose × mean insulin during OGTT]
  5. Insulinogenic index = (Insulin30 (mIU/L) − Insulin0)/(Glucose30(mmol/L) − Glucose0) during OGTT