Fig. 3

Flowchart of participation, referral and detection within the new hrHPV-based screening programme, 2017 cohort. Pearson’s chi-square test significantly different for hrHPV positivity, direct referral rates and follow-up smear (p < 0.001) and CIN2+ detection rates from direct referral (p = 0.002) between clinician-collected and self-sampling. Pearson’s chi-square test not significantly different for proportions of histology or cytology tests (from direct referral, p = 0.805; from indirect referral, p = 0.042), indirect referral rate (p = 0.974), proportions with recommendation to await next screening invitation (p = 0.884), CIN2+ detection rates from indirect referral (p = 0.319) between clinician-collected and self-sampling. N.B. Sum of advice after screening will not be 100% due to a proportion of screens with repeat cytology due to inadequate cytology quality or loss to follow-up (self-sampling arm only). Cytology was assessed in 90.1% of hrHPV-positive cases in the self-sampling arm. Repeat cytology because of inadequate cytology quality after a positive screen result was recommended in 1.3% of clinician-collected cases and 1.6% of self-sampling cases with cytology (1.3% of self-sampling cases had other recommendations). Repeat cytology because of inadequate cytology quality in a follow-up smear at 6 months was recommended in 1.5% of clinician-collected cases and 1.8% of self-sampling cases