Introduction of primary screening using high-risk HPV DNA detection in the Dutch cervical cancer screening programme: a population-based cohort study

Table 1 Findings after referrals for colposcopy by screening programme, referral type and age, per 1000 women screened

Rate per 1000 screened women	HPV								Cytology
	Direct**				Indirect**				Direct**				Indirect**
	Overall	29–39	40–54	55–61	Overall	29–39	40–54	55–61	Overall	29–39	40–54	55–61	Overall	29–39	40–54	55–61
No follow-up with cytology or histology test*	6.0	12.5	5.2	2.3	3.4	6.0	3.1	1.9	0.5	0.8	0.4	0.4	2.3	4.0	2.3	0.9
Cytology only	0.7	1.1	0.6	0.4	0.1	0.3	0.1	0.1	0.2	0.2	0.2	0.1	0.2	0.3	0.2	0.1
No dysplasia	3.9	6.5	3.9	2.0	1.6	2.6	1.5	1.0	0.6	0.8	0.5	0.5	1.8	2.8	1.8	0.9
CIN1	6.3	12.8	5.6	2.4	2.1	3.8	2.1	1.0	0.9	1.7	0.8	0.4	3.0	5.8	3.0	0.9
CIN2	4.7	10.6	4.0	1.3	1.2	2.2	1.1	0.5	2.0	4.7	1.5	0.6	2.3	4.8	2.1	0.7
CIN3	6.9	17.2	5.3	1.7	1.1	2.4	0.8	0.5	4.9	12.5	3.5	1.0	1.4	3.5	1.2	0.3
Cancer	0.4	0.9	0.4	0.1	0.0	0.0	0.0	0.0	0.3	0.6	0.3	0.1	0.0	0.1	0.0	0.0

N.B. Cases with a histological record that is coded as ‘no diagnosis’ (average of 1.2% of total cases) are included in the denominator but not presented in the table. Please refer to Additional file 1 for a comprehensive explanation of age group criteria
*These women are referred for colposcopy, but no follow-up examination has been registered in PALGA. These women are either lost to follow-up or only colposcopy is performed
**Pearson’s chi-square test significantly different for the distribution of outcomes between test types (p < 0.001)

ISSN: 1741-7015