Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records

Table 3 Five-year prevalence of symptom groups in patients prior to psychosis and matched participants

Symptom group	FEP patients (n = 3045)		Matched participants (n = 12,180)		Crude odds ratio (95% CI)^‡	Adjusted odds ratio^‡* (95% CI)
Symptom group	n^†	5-year prevalence (%)	n^†	5-year prevalence (%)	Crude odds ratio (95% CI)^‡	Adjusted odds ratio^‡* (95% CI)
Psychological symptom
Mood-related symptom	1473	48.4	1275	10.5	10.1 (9.12, 11.3)	7.60 (6.75, 8.56)
‘Neurotic’ symptom	1133	37.2	1106	9.1	6.54 (5.89, 7.27)	4.87 (4.35, 5.47)
Behavioural change	490	16.1	657	5.4	3.53 (3.08, 4.05)	2.67 (2.30, 3.09)
Change in volition	394	12.9	923	7.6	1.88 (1.64, 2.16)	1.33 (1.14, 1.55)
Perceptual problem	162	5.3	5	0.04	130 (53.7, 313)	112 (44.4, 283)
Cognitive change	38	1.3	30	0.3	5.41 (3.35, 8.75)	3.80 (2.04, 7.09)
Substance misuse	338	11.1	134	1.1	13.0 (10.4, 16.4)	8.09 (6.36, 10.3)
Physical symptom	939	30.8	1926	15.8	2.70 (2.43, 2.99)	1.80 (1.61, 2.02)

FEP first episode psychosis, CI confidence interval
^†Number of individuals with recorded symptom in the 5-year period before the index date
^‡Conditional logistic regression analyses with cluster-robust variance estimator
*Adjusted for smoking, alcohol consumption, BMI morbidity burden, and specific co-morbid conditions (including respiratory condition, musculoskeletal pain, and injury and major trauma), in addition to matched year of birth (age), gender, and practice

ISSN: 1741-7015