| Rosuvastatin (n = 48) | Aspirin (n = 40) | Placebo (n = 42) | Rosuvastatin vs placebo | Aspirin vs placebo | Rosuvastatin vs aspirin | ||||
---|---|---|---|---|---|---|---|---|---|---|
Mean (SD) | p value | Differential changeb (95% CI) | Effect sizec | p value | Differential changeb (95% CI) | Effect sizec | Differential changeb (95% CI) | |||
MADRS (depression) | ||||||||||
 Overalla | – | – | – | 0.296 | – | – | 0.467 | – | – |  |
 Baseline | 32.6 (6.1) | 32.6 (5.5) | 32.3 (6.5) |  |  | |||||
 4 weeks | 23.1 (10.2) | 22.7 (9.7) | 24.0 (9.2) |  | − 1.6 (− 5.7, 2.5) | − 0.21 | 0.357 | − 1.7 (− 5.4, 2.0) | − 0.24 | 0.0 (− 4.3, 4.3) |
 8 weeks | 19.1 (10.7) | 22.0 (11.1) | 22.1 (10.6) |  | − 3.7 (− 8.1, 0.6) | − 0.43 | 0.854 | − 0.4 (− 4.7, 3.9) | − 0.07 | 3.5 (− 8.3, 1.2) |
 12 weeks | 17.2 (11.0) | 22.9 (12.0) | 20.4 (12.4) | 0.089 | − 4.2 (− 9.1, 0.6) | − 0.44 | 0.433 | 1.9 (− 2.8, 6.6) | 0.16 | − 6.4 (− 11.7, 1.2) |
 26 weeksd | 16.0 (12.3) | 15.7 (10.4) | 13.2 (10.4) | 0.487 | 1.9 (− 3.4, 7.2) | 0.12 | 0.353 | 2.5 (− 2.7, 7.6) | 0.10 | 0.3 (− 6.0, 6.7) |