Table 1 Genomic locations of observed large deletions in AA1SA isolates
From: A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic
Coordinates | Size (BP) | Genes affected | Corresponding RD | RD coordinates | Presence | Notes |
|---|---|---|---|---|---|---|
2128380–2129581 | 1202 | glnA3, Rv1879 (glutamine synthesis) | 163 | 2127981–2128972 | AA1SA, AA1 | Additional mutations were found in other genes involved in glutamine synthesis (glnE ACG278ACA and glnA2 CTG117TTG) in all AA1SA strains |
2090364–2090443 | 81 | Rv1841c | – | – | AA1SA | Non-essential conserved hypothetical membrane protein |
2263779–2266164 | 2385 | Rv2016–Rv2019 | 175a | 2263448–2263637 | AA1SA, some AA1 | Rv2016, Rv2018 and Rv2019 are non-essential, conserved hypothetical proteins. Rv2017 is a transcriptional regulator, and essential for in vitro growth [43]. |