Fig. 6

Pathways enriched by TTC genes. a Heatmap depicts all pathways overrepresented by TTC genes (FDR < 0.05). Only pathways and ROI pairs with significant associations are displayed. The rows are pathways, and columns are ROI pairs. In the heatmap, orange points to association between pathway and one ROI in its ROI pair (asymmetric gene synchronization), and brown is the association between pathway and both ROIs in its pair (symmetric gene synchronization). Two pathway categories, Pathway Types and Signaling Types are color labeled on the left (see the “Methods” section for details). ROI pairs are labeled with Tract Info and ROI clusters. ROI clusters is based on hierarchical clustering. b The association of TTC-associated pathways depending on ROI connections to white matter tracts was examined (see the “Methods” section for details). Each circle represents pathways where green circles are tract-dependent and red circles are AD-associated tract-dependent. Associations are −log10 transformed (Y-axis), and 169 pathways are organized by Signaling Types in the X-axis (different background color in the scatter plot). The pathways associated in both tract-dependent and AD-associated tract-dependent manner are indicated by arrows with pathway names. Orange dashed line delineates P-value = 0.05, and circles below this nominal significance are made partially transparent