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Table 2 Association between diffusion parameters and disease (FDR estimated independently)

From: Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer’s disease

 ADNI3 (n = 499)ADNI2 (n = 210)
TractVolumeLengthAxDRDMDFAVolumeLengthAxDRDMDFA
FMajor0.410.830.550.090.140.020.890.180.640.070.070.08
Fminor0.410.850.064.1 × 10−30.010.410.440.590.370.260.220.16
L-ATR0.730.860.040.160.080.900.300.810.630.540.520.65
L-CAB**0.410.742.1 × 10−51.9 × 10−73.0 × 10−70.040.010.102.7 × 10−49.3 × 10− 79.2 × 10− 70.05
L-CCG0.950.960.060.020.010.390.650.650.080.950.340.46
L-CST0.860.830.210.210.170.400.620.080.060.900.510.32
L-ILF**0.710.850.020.040.020.880.540.630.040.190.050.65
L-SLFP**0.410.880.030.090.020.880.590.900.020.670.220.30
L-SLFT**0.490.880.030.110.040.710.630.651.2 × 10−30.900.180.08
L-UNC0.850.850.031.1 × 10−32.0 × 10−30.550.080.630.180.110.080.76
R-ATR0.900.870.020.100.050.750.050.650.720.460.510.63
R-CAB**0.600.634.8 × 10−31.2 × 10−52.3 × 10−50.040.060.061.2 × 10−34.2 × 10− 36.6 × 10−40.54
R-CCG0.930.854.8 × 10−30.100.010.890.690.860.080.900.510.58
R-CST0.900.950.080.260.110.490.580.240.320.900.690.54
R-ILF0.340.830.040.070.040.950.950.950.090.860.460.95
R-SLFP0.750.670.020.410.100.060.650.650.070.890.510.38
R-SLFT**0.900.850.010.390.060.070.410.900.050.650.650.06
R-UNC0.750.850.041.6 × 10−34.8 × 10−30.200.130.790.540.860.650.76
  1. The associations below FDR < 0.05 in each cohort study are presented in italics
  2. **Tracts with associations identified in ADNI3 and replicated in ADNI2
  3. Associations identified in ADNI3 and replicated in ADNI2