Fig. 9

Estimates of the potential causal effect of age at menarche on risk of sexual abuse. ALSPAC, Avon Longitudinal Study of Parents and Children; BMI, body mass index; CI, confidence interval; UKBB, UK Biobank. The ordinal response scale to sexual abuse in UK Biobank was converted to a binary variable denoting whether the participant reported any history of childhood sexual abuse, to be comparable to the replication cohort. The estimates reflect the change in risk of sexual abuse per year decrease in age at menarche after adjusting for 5 principal components. The analysis of the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort included 5953 women. For ALSPAC, the main analysis included 342 SNPs in the genetic risk score for age at menarche, while the sensitivity analysis excluding SNPs associated with BMI included 208 SNPs