Fig. 4

HIV Gag-driven replicative capacity predicts the magnitude of inflammatory cytokines and CD4⁺ T cell depletion in untreated hyperacute HIV infection. a Gag-driven replicative capacity among untreated participants. b Correlation between IP-10 in the hyperacute phase and replicative capacity. c Correlation between peak IFN-alpha and replicative capacity (* indicates two overlapping data points). d Correlation between nadir CD4⁺ T cell counts and replicative capacity. e Correlation between peak viral loads and replicative capacity. Each symbol represents an individual participant (N = 12). Statistical test: Spearman’s rank-order correlation. P values < 0.05 were considered significant