Fig. 5

The magnitude of plasma cytokines predicts CD4⁺ T cell and viral load dynamics in untreated hyperacute HIV infection. a Correlation between peak IFN-alpha and peak viremia. b Correlation between hyperacute soluble IL-2 receptor and peak viremia. c Correlation between hyperacute IL-1RA and viral load set point. d Correlation between hyperacute CXCL13 and nadir CD4⁺ T cell counts. e Correlation between hyperacute soluble IL-2 receptor and nadir CD4⁺ T cell counts. f Correlation between hyperacute IL-1RA and set point CD4⁺ T cell counts. Each symbol represents an individual participant (N = 12 except CXCL13 with N = 10). Statistical test: Spearman’s rank-order correlation. P values < 0.05 were considered significant