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Table 2 Linear regression analyses to determine the prediction of inflammatory cytokines and CD4+ T cell counts by Gag-protease-driven viral replicative capacity

From: Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

Outcome variable Predictor variable Univariable analyses Multivariable analyses
Coefficient (95% CI) P value Coefficient (95% CI) P value
IP-10 at 1 week (log10 pg/mL)a Replicative capacity 1.41 (0.13–2.69) 0.034 1.61 (0.28–2.95) 0.023
Peak viral loadb − 0.04 (− 0.38–0.29) 0.777 − 0.14 (− 0.42–0.13) 0.274
Peak IFN-alpha (log10 pg/mL) a Replicative capacity 3.32 (0.12–6.53) 0.044 2.70 (− 0.52–5.93) 0.091
Peak viral loadb 0.60 (− 0.11–1.31) 0.088 0.43 (− 0.24–1.10) 0.176
Nadir CD4+ T cell counts (cells/μL) Replicative capacity − 483.67 (− 1013.23–45.88) 0.069 − 396.22 (− 945.81–153.37) 0.137
Peak viral loadb − 85.69 (− 201–30.15) 0.130 − 61.41 (− 175.42–52.60) 0.254
  1. Significant associations and non-significant trends are shown in bold
  2. Number of participants in the analyses (N), 12
  3. aPlasma cytokine levels were log10-transformed to attain normal distribution
  4. bPeak viral load was expressed in log10 RNA copies/mL