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Table 2 Linear regression analyses to determine the prediction of inflammatory cytokines and CD4+ T cell counts by Gag-protease-driven viral replicative capacity

From: Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

Outcome variablePredictor variableUnivariable analysesMultivariable analyses
Coefficient (95% CI)P valueCoefficient (95% CI)P value
IP-10 at 1 week (log10 pg/mL)aReplicative capacity1.41 (0.13–2.69)0.0341.61 (0.28–2.95)0.023
Peak viral loadb− 0.04 (− 0.38–0.29)0.777− 0.14 (− 0.42–0.13)0.274
Peak IFN-alpha (log10 pg/mL) aReplicative capacity3.32 (0.12–6.53)0.0442.70 (− 0.52–5.93)0.091
Peak viral loadb0.60 (− 0.11–1.31)0.0880.43 (− 0.24–1.10)0.176
Nadir CD4+ T cell counts (cells/μL)Replicative capacity− 483.67 (− 1013.23–45.88)0.069− 396.22 (− 945.81–153.37)0.137
Peak viral loadb− 85.69 (− 201–30.15)0.130− 61.41 (− 175.42–52.60)0.254
  1. Significant associations and non-significant trends are shown in bold
  2. Number of participants in the analyses (N), 12
  3. aPlasma cytokine levels were log10-transformed to attain normal distribution
  4. bPeak viral load was expressed in log10 RNA copies/mL