Skip to main content

Table 2 Linear regression analyses to determine the prediction of inflammatory cytokines and CD4+ T cell counts by Gag-protease-driven viral replicative capacity

From: Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

Outcome variable

Predictor variable

Univariable analyses

Multivariable analyses

Coefficient (95% CI)

P value

Coefficient (95% CI)

P value

IP-10 at 1 week (log10 pg/mL)a

Replicative capacity

1.41 (0.13–2.69)

0.034

1.61 (0.28–2.95)

0.023

Peak viral loadb

− 0.04 (− 0.38–0.29)

0.777

− 0.14 (− 0.42–0.13)

0.274

Peak IFN-alpha (log10 pg/mL) a

Replicative capacity

3.32 (0.12–6.53)

0.044

2.70 (− 0.52–5.93)

0.091

Peak viral loadb

0.60 (− 0.11–1.31)

0.088

0.43 (− 0.24–1.10)

0.176

Nadir CD4+ T cell counts (cells/μL)

Replicative capacity

− 483.67 (− 1013.23–45.88)

0.069

− 396.22 (− 945.81–153.37)

0.137

Peak viral loadb

− 85.69 (− 201–30.15)

0.130

− 61.41 (− 175.42–52.60)

0.254

  1. Significant associations and non-significant trends are shown in bold
  2. Number of participants in the analyses (N), 12
  3. aPlasma cytokine levels were log10-transformed to attain normal distribution
  4. bPeak viral load was expressed in log10 RNA copies/mL