Fig. 1From: Investigation of the impact of the NICE guidelines regarding antibiotic prophylaxis during invasive dental procedures on the incidence of infective endocarditis in England: an electronic health records studyMonthly cases of infective endocarditis. Different coloured lines represent different inclusion criteria. a Raw cases. b Raw cases after applying a non-parametric LOWESS smoother. c Effect of applying different methods to adjust for changes in population, shown here for all cases using Criteria A, but results are similar for all three criteria (see Additional file 2: Figure S1)Back to article page