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Table 1 Baseline characteristics of pregnant women assessed for stillbirth

From: Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Characteristic

All

AL

ASAQ

ASMQ

DP

AAP

AS

ASSP

Q

QC

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

N

% (N)

Mean (SD)

EGA (week)

4334

24.6 (5.7)

1087

24.3 (5.7)

775

24.1 (5.1)

965

25.3 (5.3)

837

24.4 (5.7)

81

26.2 (7.1)

193

26.6 (7.4)

154

24.4 (5.8)

184

23.8 (6.3)

58

26.8 (6.5)

Age group <20

4334

32.0 (1388)

1087

36.5 (397)

775

31.7 (246)

965

28.1 (271)

837

39.8 (333)

81

28.4 (23)

193

19.2 (37)

154

20.1 (31)

184

20.7 (38)

58

20.7 (12)

 20–24

 

32.3 (1399)

 

31.1 (338)

 

31.6 (245)

 

33.6 (324)

 

30.0 (251)

 

27.2 (22)

 

24.9 (48)

 

55.2 (85)

 

39.7 (73)

 

22.4 (13)

 25–29

 

19.3 (836)

 

17.8 (194)

 

20.1 (156)

 

21.2 (205)

 

16.6 (139)

 

22.2 (18)

 

21.2 (41)

 

17.5 (27)

 

20.1 (37)

 

32.8 (19)

 30–34

 

9.7 (419)

 

8.1 (88)

 

10.7 (83)

 

10.6 (102)

 

8.4 (70)

 

13.6 (11)

 

14.5 (28)

 

3.9 (6)

 

13.0 (24)

 

12.1 (7)

 >35 (years)

 

6.7 (292)

 

6.4 (70)

 

5.8 (45)

 

6.5 (63)

 

5.3 (44)

 

8.6 (7)

 

20.2 (39)

 

3.2 (5)

 

6.5 (12)

 

12.1 (7)

Gravidity 1

4297

35.4 (1519)

1053

35.1 (370)

774

36.4 (282)

965

33.2 (320)

837

38.4 (321)

81

29.6 (24)

193

27.5 (53)

154

48.7 (75)

182

32.4 (59)

58

25.9 (15)

 2

 

23.4 (1005)

 

23.2 (244)

 

22.5 (174)

 

24.1 (233)

 

24.9 (208)

 

21.0 (17)

 

15.0 (29)

 

24.7 (38)

 

25.8 (47)

 

25.9 (15)

 ≥3

 

41.3 (1773)

 

41.7 (439)

 

41.1 (318)

 

42.7 (412)

 

36.8 (308)

 

49.4 (40)

 

57.5 (111)

 

26.6 (41)

 

41.8 (76)

 

48.3 (28)

Parity 0

4329

42.7 (1847)

1083

42.6 (461)

774

41.1 (318)

965

42.6 (411)

837

47.6 (398)

81

33.3 (27)

193

30.1 (58)

154

56.5 (87)

184

37.0 (68)

58

32.8 (19)

 1

 

21.8 (945)

 

20.9 (226)

 

22.4 (173)

 

20.9 (202)

 

22.6 (189)

 

24.7 (20)

 

19.7 (38)

 

23.4 (36)

 

25.0 (46)

 

25.9 (15)

 ≥2

 

35.5 (1537)

 

36.6 (396)

 

36.6 (283)

 

36.5 (352)

 

29.9 (250)

 

42.0 (34)

 

50.3 (97)

 

20.1 (31)

 

38.0 (70)

 

41.4 (24)

Height (cm)

3809

155.8 (6.9)

934

156.1 (6.6)

775

157.9 (6.5)

927

156.1 (7.3)

837

155.3 (6.3)

33

150.2 (8.3)

136

151.7 (5.6)

118

150.0 (7.0)

49

153.3 (5.1)

0

 

Weight (kg)

4333

53.9 (8.3)

1086

53.7 (7.4)

775

56.3 (8.8)

965

54.0 (8.5)

837

54.4 (8.2)

81

49.8 (6.6)

193

49.5 (6.4)

154

47.8 (6.9)

184

55.2 (9.4)

58

49.8 (5.5)

BMI <18.5

3809

6.3 (239)

934

5.8 (54)

775

4.9 (38)

927

6.8 (63)

837

5.5 (46)

33

6.1 (2)

136

8.1 (11)

118

18.6 (22)

49

6.1 (3)

0

 

 18.5–24.9

 

79.9 (3044)

 

84.7 (791)

 

78.8 (611)

 

77.9 (722)

 

77.8 (651)

 

78.8 (26)

 

83.8 (114)

 

72.0 (85)

 

89.8 (44)

  

 25.0–29.9

 

12.0 (458)

 

8.9 (83)

 

12.4 (96)

 

13.4 (124)

 

15.4 (129)

 

9.1 (3)

 

7.4 (10)

 

9.3 (11)

 

4.1 (2)

  

 ≥30 (kg/m2)

 

1.8 (68)

 

0.6 (6)

 

3.9 (30)

 

1.9 (18)

 

1.3 (11)

 

6.1 (2)

 

0.7 (1)

 

0.0 (0)

 

0.0 (0)

  

Fever (temperature >37.5°C)

4292

9.2 (395)

1086

8.2 (89)

775

4.8 (37)

964

9.8 (94)

834

4.2 (35)

81

24.7 (20)

193

25.4 (49)

117

24.8 (29)

184

16.8 (31)

58

19.0 (11)

Haemoglobin on day 0 (g/dL)

4308

10.0 (1.4)

1075

10.2 (1.4)

775

10.0 (1.3)

963

9.9 (1.4)

834

10.0 (1.4)

80

9.4 (1.5)

193

9.5 (1.5)

152

9.3 (1.4)

179

10.2 (1.8)

57

9.1 (1.6)

Parasitaemia (log10/μL)

4334

3.0 (0.9)

1087

3.1 (0.8)

775

2.8 (0.8)

965

3.0 (0.8)

837

2.9 (0.8)

81

3.6 (1.1)

193

3.3 (1.0)

154

3.4 (0.8)

184

3.4 (0.9)

58

3.3 (1.1)

Presence of gametocytes

4271

3.8 (161)

1083

3.9 (42)

775

3.0 (23)

946

1.7 (16)

837

3.8 (32)

81

3.7 (3)

189

10.1 (19)

118

3.4 (4)

184

9.2 (17)

58

8.6 (5)

Mixed infection

4334

0.7 (32)

1087

0.9 (10)

775

0.0 (0)

965

0.0 (0)

837

0.7 (6)

81

1.2 (1)

193

6.2 (12)

154

0.0 (0)

184

0.0 (0)

58

5.2 (3)

HIV infection

2730

1.3 (35)

808

1.4 (11)

573

0.5 (3)

570

0.2 (1)

668

0.9 (6)

0

 

0

 

27

22.2 (6)

84

9.5 (8)

0

 
  1. AAP artesunate with atovaquone-proguanil, AL artemether-lumefantrine, AS artesunate monotherapy, ASAQ artesunate-amodiaquine, ASMQ artesunate-mefloquine, ASSP artesunate-sulfadoxine-pyrimethamine, BMI body mass index, DP dihydroartemisinin-piperaquine, EGA estimated gestational age, HIV human immunodeficiency virus, Q quinine monotherapy, QC quinine with clindamycin, SD standard deviation